CHARACTERIZATION OF THE ATAXIA-TELANGIECTASIA GENE PRODUCT
CHARACTERIZATION OF THE ATAXIA-TELANGIECTASIA GENE PRODUCT
批准号:
6109005
负责人:
D A TAGLE
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
共济失调毛细血管扩张症(AT)是一种常染色体隐性遗传病
英文摘要
Ataxia-telangiectasia (AT) is an autosomal recessive
disorder characterized by oculocutaneous telangiectasias and
progressive neuromotor dysfunction, cellular and humoral immune
deficiencies, hypersensiticvity to ionizing radiation and increased
predisposition to leukemias and lymphomas. The AT gene (ATM)
encodes a 350 kD protein that acts as a serine/thereonine kinase by
activating p53, a key molecule involved in the regulation of
apoptosis and cell cycle. Antibodies generated against ATM protein
are being used to study the other functional domains of the protein.
In addition, an ATM DNA chip was developed and tested in order
to faciliate the identification of carriers for the mutation. This will
allow the testing of the link between carrier status and increased
susceptibility for various malgnancies, including breast cancer.
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CLONING AND FUNCTIONAL CHARACTERIZATION OF INHERITED NEURODEGENERATIVE DISORDERS
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批准号:2345084
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
DEVELOPMENT OF CELLULAR AND ANIMAL MODELS FOR HUNTINGTONS DISEASE
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批准号:2456803
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
CANDIDATE GENE ANALYSIS--INTEGRATIVE EFFORT TO CLONE NIEMANN-PICK TYPE C DISEASE
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批准号:2456801
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
CANDIDATE GENE ANALYSIS--INTEGRATIVE EFFORT TO CLONE NIEMANN-PICK TYPE C DISEASE
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批准号:6162594
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
DEVELOPMENT OF CELLULAR AND ANIMAL MODELS FOR HUNTINGTONS DISEASE
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批准号:6109006
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
CANDIDATE GENE ANALYSIS--INTEGRATIVE EFFORT TO CLONE NIEMANN-PICK TYPE C DISEASE
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批准号:6109004
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
CHARACTERIZATION OF THE ATAXIA-TELANGIECTASIA GENE PRODUCT
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批准号:2456802
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
DEVELOPMENT OF CELLULAR AND ANIMAL MODELS FOR HUNTINGTONS DISEASE
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批准号:6162596
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
CHARACTERIZATION OF THE ATAXIA-TELANGIECTASIA GENE PRODUCT
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批准号:6162595
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D A TAGLE
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依托单位:
海外基金