CoEN5028 Can a dysfunction of the basal ganglia and related low level nociceptive network underlie some central neuropathic pain symptoms in..

CoEN5028 基底神经节和相关低水平伤害性网络的功能障碍是否是某些中枢神经性疼痛症状的基础。

• 批准号: MR/V006525/1
• 负责人: Oliver Bandmann
• 金额: $ 41万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FV006525%2F1
• 关键词: CoEN5028; dysfunction; basal; ganglia; related

Pain is a very common and troublesome, but poorly understood symptom in Parkinson's disease (PD). Central neuropathic pain in PD is often described by patients as otherwise unexplained painful sensations with no apparent origin, predominantly on the more affected side. Central neuropathic pain is thought to originate from a dysfunction of the central nervous system suggesting that the brain circuits that allow us to perceive and process pain could be dysfunctional in Parkinson's disease. While abnormal nociceptive processing has been reported in some cortical structures involved in pain, there is to date no clear pathophysiological mechanism to explain these specific symptoms. Based on our recent discovery of a novel nociceptive network, we propose to test a new hypothesis linking central neuropathic pain symptoms to abnormal activity of this nociceptive network between the basal ganglia, a group of structures known to be dysfunctional in Parkinson's disease, and a primary nociceptive structure within the brainstem, the parabrachial nucleus. We also propose to test whether this network could underlie the beneficial effect of deep brain stimulation of the subthalamic nucleus on central pain symptoms.

疼痛是帕金森病（PD）中一种非常常见和麻烦的症状，但人们对其了解甚少。PD的中枢神经性疼痛通常被患者描述为无法解释的疼痛感觉，没有明显的来源，主要发生在更受影响的一侧。中枢神经性疼痛被认为起源于中枢神经系统的功能障碍，这表明在帕金森病中，允许我们感知和处理疼痛的大脑回路可能出现功能障碍。虽然在一些与疼痛有关的皮质结构中有异常的伤害性加工的报道，但迄今为止还没有明确的病理生理机制来解释这些特定的症状。基于我们最近发现的一种新的伤害感受网络，我们提出测试一种新的假设，将中枢神经性疼痛症状与基底节区（一组已知在帕金森病中功能失调的结构）和脑干内的主要伤害感受结构（臂旁核）之间的伤害感受网络异常活动联系起来。我们还建议测试这个网络是否可能是丘脑下核深部脑刺激对中枢性疼痛症状有益作用的基础。