BIOMARKERS OF OXIDANT STRESS IN ARDS
ARDS 氧化应激的生物标志物
基本信息
- 批准号:6202606
- 负责人:
- 金额:$ 15.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-01 至 2000-08-31
- 项目状态:已结题
- 来源:
- 关键词:adult respiratory distress syndrome antioxidants biomarker blood chemistry chemoprevention clinical research clinical trial phase I diagnosis design /evaluation disease /disorder proneness /risk drug screening /evaluation human subject human therapy evaluation oxidative stress pathologic process respiratory disorder epidemiology tocopherols urinalysis
项目摘要
Project 3's long term goal is to develop new interventions that can
favorably change the oxidant-antioxidant imbalance in subgroups of
patients at risk for ARDS and characterized by high oxidant stress in
order to prevent ARDS from occurring and, if it does occur in these
patients, to reduce its severity and associated morbidity and mortality.
Project 3 has the following four Specific Aims:
1. To test the hypothesis that elevated levels of selected biomarkers of
oxidant stress are risk factors for the development of acute lung injury
(ALI) or ARDS after trauma or sepsis, two nested case-control studies will
be conducted within prospective cohorts of patients with trauma or sepsis.
Levels of three biomarkers, serum protein 3-nitrotyrosine and carbonyls,
and a urinary isoprostane (IPF2 alpha-I), will be related to the
subsequent occurrence of ALI or ARDS in a multivariate statistical model.
Controls will be selected from the same target population and control
samples for biomarker analysis will be matched with cases on the basis of
being from the same time after onset of trauma or sepsis.
2. To test the hypothesis that elevations in selected biomarkers of
oxidant stress coincide with the onset of ALI/ARDS after major trauma or
severe sepsis, two nested case-control studies will be conducted within
the same cohorts described in Specific Aim 1. Levels of the same
biomarkers (as listed above) from the first 48 hours after the onset of
ALI or ARDS in cases will be compared with those obtained from matched
controls.
3. To test the hypothesis that elevated levels of biomarkers of oxidant
stress at the onset of ARDS due to trauma or sepsis are risk factors for
prolonged respiratory failure, organ system failure and mortality, the
same biomarkers listed in Specific Aim 1 at the onset of ARDS in patients
due to trauma or sepsis will be compared (by multivariate statistical
methods) with three outcomes (all at 28 days after onset of ARDS): 1.
ventilator-free days, 2. organ failure free days and 3. mortality.
4. To test the hypothesis that administering a systemic anti-oxidant
decreases the levels of biomarkers of oxidant stress in patients with ARDS
due to trauma or sepsis, a randomized, double-blinded, placebo controlled
study will be conducted to assess the effects of dl-alpha-tocopherol on
the biomarkers in Specific Aim 1 in early ARDS due to trauma or sepsis.
项目3的长期目标是开发新的干预措施,
有利地改变亚组中的氧化剂-抗氧化剂失衡,
有ARDS风险且以高氧化应激为特征的患者,
为了防止ARDS的发生,如果它确实发生在这些
患者,以降低其严重程度和相关的发病率和死亡率。
项目3有以下四个具体目标:
1.为了检验这一假设,选择的生物标志物的水平升高,
氧化应激是急性肺损伤发生的危险因素
(ALI)或创伤或脓毒症后的ARDS,两项巢式病例对照研究将
在创伤或脓毒症患者的前瞻性队列中进行。
三种生物标志物(血清蛋白3-硝基酪氨酸和羰基)的水平,
和尿异前列腺素(IPF 2 α-I),将与
多变量统计模型中随后发生的ALI或ARDS。
对照将从相同的目标人群和对照中选择
用于生物标志物分析的样本将根据以下因素与病例匹配:
是在创伤或败血症发作后的同一时间。
2.为了检验以下假设:
氧化应激与严重创伤后ALI/ARDS的发作一致,
严重脓毒症,将进行两项巢式病例对照研究,
具体目标1中描述的相同队列。水平相同
从发病后第一个48小时的生物标志物(如上所列)
病例中的ALI或ARDS将与从匹配的
对照
3.为了验证氧化剂生物标志物水平升高
由于创伤或败血症引起的ARDS发作时的应激是
长期呼吸衰竭、器官系统衰竭和死亡率,
患者ARDS发作时特定目标1中列出的相同生物标志物
由于创伤或脓毒症将进行比较(通过多变量统计
方法),有三个结果(均在ARDS发作后28天):1.
无呼吸机天数,2.无器官衰竭天数和3. mortality.
4.为了验证一个假设,给予全身性抗氧化剂
降低ARDS患者的氧化应激生物标志物水平
由于创伤或败血症,随机、双盲、安慰剂对照
将进行研究以评估DL-α-生育酚对
Specific Aim 1中的生物标志物在创伤或脓毒症所致的早期ARDS中的作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(1)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
PAUL N LANKEN其他文献
PAUL N LANKEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('PAUL N LANKEN', 18)}}的其他基金
CORE--Clinical, Biostatistical and Data Management
核心——临床、生物统计和数据管理
- 批准号:
7796693 - 财政年份:2009
- 资助金额:
$ 15.58万 - 项目类别:
CORE--Clinical, Biostatistical and Data Management
核心——临床、生物统计和数据管理
- 批准号:
6968188 - 财政年份:2004
- 资助金额:
$ 15.58万 - 项目类别:
CCTG FOR CLINICAL NETWORK FOR ARDS TREATMENT
ARDS 治疗临床网络的 CCTG
- 批准号:
2317286 - 财政年份:1994
- 资助金额:
$ 15.58万 - 项目类别:
CCTG FOR CLINICAL NETWORK FOR ARDS TREATMENT
ARDS 治疗临床网络的 CCTG
- 批准号:
6358881 - 财政年份:1994
- 资助金额:
$ 15.58万 - 项目类别:
CCTG FOR CLINICAL NETWORK FOR ARDS TREATMENT
ARDS 治疗临床网络的 CCTG
- 批准号:
2831377 - 财政年份:1994
- 资助金额:
$ 15.58万 - 项目类别:
相似海外基金
Enhancing gamete cryoprotective properties of graphene oxide by dual functionalization with antioxidants and non-penetrating cryoprotectant molecules
通过抗氧化剂和非渗透性冷冻保护剂分子的双重功能化增强氧化石墨烯的配子冷冻保护特性
- 批准号:
24K18002 - 财政年份:2024
- 资助金额:
$ 15.58万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
SBIR Phase I: Sustainable antioxidants for industrial process fluids
SBIR 第一阶段:工业过程流体的可持续抗氧化剂
- 批准号:
2222215 - 财政年份:2023
- 资助金额:
$ 15.58万 - 项目类别:
Standard Grant
Development of a new bone augmentation method that enables long-term survival and long-term functional expression of transplanted cells by antioxidants
开发一种新的骨增强方法,通过抗氧化剂使移植细胞能够长期存活和长期功能表达
- 批准号:
23K09272 - 财政年份:2023
- 资助金额:
$ 15.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Non-Invasive Probing Cellular Oxidative Stress and Antioxidants Therapeutic Effectiveness
非侵入性探测细胞氧化应激和抗氧化剂的治疗效果
- 批准号:
10652764 - 财政年份:2023
- 资助金额:
$ 15.58万 - 项目类别:
Mitochondria-targeting Novel Cationic Hydrazone Antioxidants for the Treatment of Preeclampsia
线粒体靶向新型阳离子腙抗氧化剂用于治疗先兆子痫
- 批准号:
10730652 - 财政年份:2023
- 资助金额:
$ 15.58万 - 项目类别:
Effects of different doses of antioxidants(Vitamin E) intake on exercise induced oxidative stress, antioxidative capacity and chronic inflammation
不同剂量抗氧化剂(维生素E)摄入对运动引起的氧化应激、抗氧化能力和慢性炎症的影响
- 批准号:
22K11609 - 财政年份:2022
- 资助金额:
$ 15.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Contribution of antioxidants to regeneration of rotator cuff insertion
抗氧化剂对肩袖插入再生的贡献
- 批准号:
22K16720 - 财政年份:2022
- 资助金额:
$ 15.58万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Latent Antioxidants for Environmentally Responsible Polymer Formulations
用于环保聚合物配方的潜在抗氧化剂
- 批准号:
RGPIN-2018-04107 - 财政年份:2022
- 资助金额:
$ 15.58万 - 项目类别:
Discovery Grants Program - Individual
Polyunsaturated fatty acid (PUFA), inflammation and antioxidants
多不饱和脂肪酸 (PUFA)、炎症和抗氧化剂
- 批准号:
RGPIN-2019-05674 - 财政年份:2022
- 资助金额:
$ 15.58万 - 项目类别:
Discovery Grants Program - Individual
Suppressed methemoglobin formation of artificial red cell by liposomal antioxidants and its mechanism.
脂质体抗氧化剂抑制人工红细胞高铁血红蛋白形成及其机制
- 批准号:
22K12824 - 财政年份:2022
- 资助金额:
$ 15.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)