VARIED DOSES OF TRIVALENT INFLUENZA BY JET INJECTOR

与传统的针头和注射器（N&S）免疫接种相比，通过喷射注射器（JI）接种疫苗具有几个潜在的优势。首先是潜在的免疫原性的改善，这可能允许使用更低剂量的疫苗。这可能会降低每剂疫苗的成本，或允许使用目前的生产方法提高剂量产量。其次，注射疫苗可能与抗体滴度更快上升有关，从而在接种疫苗后更迅速地产生保护作用。第三是减少发展中国家由于卫生用品消毒不当和利器处置不当而造成的血源性病原体传播的风险。最后，JI管理可能比N&S管理更少痛苦。在这项研究中，健康成人将接种不同剂量的流感疫苗，由JI和N&S。如果JI给药在耐受性、免疫原性或抗体上升动力学方面具有优势，这将支持在成人和儿童人群中进一步开发和测试JI设备。

Administration of vaccines by jet injector (JI) offers several potential advantages over the traditional needle and syringe (N&S) administration of immunizations. The first is potentially improved immunogenicity, which may allow for lower doses of vaccine to be administered. This may reduce the cost per dose of vaccine or allow for a higher dose yield with current production methods. Second, JI administration may be associated with a more rapid rise in antibody titer, resulting in a more immediate conference of protection following vaccination. The third is a reduction of the risk of transmission of blood borne pathogens resulting from improper sterilization of N&S's and inadequate disposal of sharps in developing countries. Lastly, JI administration may be less painful than N&S administration. In this study, healthy adults will be vaccinated with varyng doses of influenza vaccine, by JI and N&S. If adminstration by JI is associated with advantages in terms of tolerability, immunogenicity, or kinetics of antibody rise, this will support further efforts to develop and test JI devices in both adult and pediatric populations.