STUDIES ON THE GENETICS OF NONINSULIN DEPENDENT DIABETES MELLITUS (NIDDM)

非胰岛素依赖型糖尿病（NIDDM）遗传学（GENNID）研究的目标是基于从受影响的兄弟姐妹中确定的谱系，为NIDDM的连锁和类似研究收集可再生的遗传物质来源。在当前期间（1998年1月12日至1999年1月12日），我们将招募30个扩展谱系，包括至少两个受影响的兄弟姐妹，一个未受影响的配偶控制，以及未受影响的兄弟姐妹和父母（如果有的话）。临床和家族史将记录在一个永久的数据库中，以及相关的实验室研究，包括胰岛b细胞功能、胰岛素作用、肾功能和脂质代谢的测量。永久细胞系将被建立，以获得无限的DNA来源。此外，将招募30个家庭，只研究受影响的兄弟姐妹对。这一资源将为未来的研究人员寻求糖尿病表型的基因型决定因素提供必要的材料。

The goal of the Genetics of Non-Insulin Dependent Diabetes Mellitus (NIDDM) (GENNID) study is to collect a renewable source of genetic material for linkage an similar studies of NIDDM, bases upon pedigrees ascertained from an affected sibling pair. During the current period (12/1/98 - 12/1/99) wee will recruit 30 extended pedigrees, including at least two affected sibs, an unaffected spouse control, and unaffected sibs and parents when available. Clinical and family histories will be recorded in a permanent databae, along wit pertinent laboratory studies including measures of pancreatic islet b-cell function, insulin action, renal function, and lipid metabolism. Permnent cell lines will be established for an unlimited source of DNA. In addition, 30 families will be recruited with only affected sib pairs studied. This resource will provide the necessary materials for future investigators to pursue the genotypic determinants of diabetic phenotypes.