MULTICENTER TRIAL OF EFFECT OF PERIOSTAT ON ADULT PERIODONTITIS

胶原蛋白是骨和其他结缔组织（如牙周韧带中的牙龈）的主要结构蛋白。 胶原纤维是牙齿附着在骨头上的方式。 在牙周炎期间，胶原蛋白的破坏通过在活动性疾病部位发现的活性哺乳动物胶原酶发生。 强力霉素是一种胶原酶抑制剂，已被证明在非抗菌剂量下有效降低与活动性牙周炎相关的胶原酶水平升高。本研究的目的是评价Periostat胶囊20 mg b.i.d.的临床效果。联合SRP与安慰剂胶囊b.i.d.结合SRP。

Collagen is the major structural protien in bone and other connective tissues, such as the gingivia in periodental ligament. Collagen fibers are the means by which the tooth is attached to the bone. During periodontitus, destruction of collagen takes place by active mammalian collagenase which is found at the site of active disease. Doxycycline, an inhibitor of collagenase, has been shown to be effective at non-antimicrobial doses in reducing elevated levels of collagenase associated with active periodontitus. The objective of this study is to evaluate the clinical effects of Periostat capsules 20 mg b.i.d. in conjunction with SRP versus placebo capsules b.i.d. in conjunction with SRP.