MULTICENTER TRIAL OF EFFECT OF PERIOSTAT ON ADULT PERIODONTITIS

胶原蛋白是骨骼和其他结缔组织中的主要结构蛋白，如牙周韧带中的牙龈。胶原蛋白纤维是牙齿与骨骼连接的方式。在牙周病期间，胶原蛋白被活跃的哺乳动物胶原酶破坏，胶原酶位于活动性疾病的部位。多西环素是一种胶原酶抑制剂，已被证明在非抗菌剂量下有效降低与活动性牙周炎相关的胶原酶水平升高。本研究的目的是评价派里奥斯特胶囊20 mg，tid的临床疗效。联合SRP与安慰剂胶囊b.i.d。与SRP相结合。

Collagen is the major structural protien in bone and other connective tissues, such as the gingivia in periodental ligament. Collagen fibers are the means by which the tooth is attached to the bone. During periodontitus, destruction of collagen takes place by active mammalian collagenase which is found at the site of active disease. Doxycycline, an inhibitor of collagenase, has been shown to be effective at non-antimicrobial doses in reducing elevated levels of collagenase associated with active periodontitus. The objective of this study is to evaluate the clinical effects of Periostat capsules 20 mg b.i.d. in conjunction with SRP versus placebo capsules b.i.d. in conjunction with SRP.