丁硫氨酸亚磺酰亚胺联合美法仑治疗神经母细胞瘤的试验-猫眼课题宝

丁硫氨酸亚磺酰亚胺联合美法仑治疗神经母细胞瘤的试验

批准号：

6113655

负责人：

CLARK ANDERSON

金额：

$3.56万

依托单位：

UNIVERSITY OF SOUTHERN CALIFORNIA

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 1999-11-30

来源：

https://reporter.nih.gov/project-details/6113655

关键词：

buthionine sulfoximine child (0-11) clinical research drug screening /evaluation glutathione human subject lymphocyte melphalan neoplasm /cancer chemotherapy neuroblastoma pediatric neoplasm /cancer pediatric pharmacology pharmacokinetics

中文摘要

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英文摘要

Treatment failure in neuroblastoma likely involves acquired alkylator resistance and the anti-tumor effect of alkylating agents may be increased by depletion of glutathione (GSH) with the drug buthionine sulfoximine (BSO). This study will evaluate the pharmacokinetics and clinical toxicities of the combination of (BS0) and melphalan in pediatric patients with neuroblastoma. An additional goal of this study is to document GSH depletion in peripheral blood lymphocytes, normal marrow and neuroblastoma cells found in the bone marrow.

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