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GENETICS OF GRAFT VERSUS HOST DISEASE

GENETICS OF GRAFT VERSUS HOST DISEASE
移植物抗宿主疾病的遗传学
批准号:
6297189
负责人:
David Ginsburg
金额:
$0.02万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-12-01 至 1999-11-30

项目摘要

项目成果

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中文摘要
翻译
该项目的总体目标是确定除人类白细胞抗原以外的导致移植物抗宿主病(GVHD)的基因(S)。GCRC的遗传学核心设施将用于从确定的研究对象生产永生化细胞系。淋巴细胞将被EBV永生化,目的是为分析提供可再生的细胞和DNA。这些淋巴母细胞的可获得性将有助于描述特定基因(S)。
英文摘要
The overall aim of this project is to identify the gene(s) other than HLA that contribute to Graft-versus-host disease (GVHD). The Genetics Core Facility of the GCRC would be utilized for the production of immortalized cell lines from research subjects, as they are identified. Lymphocytes will be immortalized with EBV for the purpose of providing a renewable supply of cells and DNA for analysis. The availability of these lymphoblast cells will facilitate delineation of the specific gene(s).
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