USE OF OXYMETAZOLINE TO CONTROL BLEEDING IN SELECTED DENTAL PROCEDURES

在特定牙科手术中使用羟甲唑啉控制出血

• 批准号: 6113522
• 负责人: EDDIE L BOYD
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6113522
• 关键词: adrenergic agents; blood pressure; clinical research; dental agent; dental pharmacology; drug screening /evaluation; gingiva; gingival sulcus; heart rate; hemorrhage; human subject; imidazole; slow release drug

Gingival retraction is regarded as an important step in dental restorative procedures. Frequently, the margins of inlays, amalgams or crowns are extended subgingivally due to caries, existing restorations, esthetic demands, or the need for additional retention. The majority of dentists use epinephrine-impregnated cords for gingival displacement and to control bleeding. The use of epinephrine is potentially hazardous and must be used with caution in patients undergoing dental procedures. The objectives of this study are to evaluate oxymetazoline to determine if it can be used to control bleeding in the gingival sulcus and its effects on blood pressure, pulse rate and heart rate when used in this manner.

牙周回缩被认为是牙齿修复过程中的一个重要步骤。通常，嵌体、银汞合金或全冠的边缘由于龋齿、现有修复体、美学要求或额外固位的需要而延伸到龈下。大多数牙医使用肾上腺素浸渍的牙线进行牙周移位和止血。肾上腺素的使用有潜在的危险，在接受牙科手术的患者中必须谨慎使用。本研究的目的是评估羟甲唑啉，以确定它是否可以用于控制牙龈沟出血，以及当以这种方式使用时，它对血压、脉率和心率的影响。