LABETALOL TO TREAT CHRONIC CONGESTIVE HEART FAILURE IN CHILDREN & ADOLESCENTS

拉贝洛尔治疗儿童慢性充血性心力衰竭

• 批准号: 6263662
• 负责人: COLLIN G COWLEY
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263662
• 关键词: adolescence (12-20); alpha antiadrenergic agent; beta antiadrenergic agent; cardiovascular stress test; child (0-11); clinical research; clinical trials; congestive heart failure; echocardiography; electrocardiography; heart disorder chemotherapy; heart function; human subject; human therapy evaluation; pediatric pharmacology; quality of life

Chronic congestive heart failure (CHF) in children represents a final common pathway resulting from congenital or aquired heart disease. Despite standard therapy with digoxin, diuretics, and angiotensin converting enzyme inhibitors, many children eventually require heart transplantation to prolong survival. Adrenergic blockade has been employed in adults suffering from congestive heart failure with resultant decreased morbidity and mortality. Because of these promising results in adults, we propose to examine the effects of labetalol, a nonselective beta-and selective alpha-1 adrenergic blocking agent, in the treatment, we intend to obtain exercise tolerance tests, electrocardiograms, and echocardiograms in 20 children before treatment, after 4 and 6 months of maintenance therapy, and again 2 weeks after labetalol therapy has been discontinued. The significance of this study is the potential for the development of new approaches to the treatment of chronic CHF in children. The use of labetalol in this setting has the potential to improve cardiac function, improve the quality of life, prolong survival, reduce medical care costs, and postpone or preclude the need for heart transplantation.

儿童慢性充血性心力衰竭（CHF）是先天性或获得性心脏病导致的最终常见途径。 尽管使用地高辛、利尿剂和血管紧张素转换酶抑制剂进行标准治疗，但许多儿童最终需要心脏移植来延长生存期。 肾上腺素能受体阻滞剂已被用于患有充血性心力衰竭的成人，从而降低了发病率和死亡率。 由于这些有希望的结果在成人中，我们建议检查拉贝洛尔，一种非选择性β-和选择性α-1肾上腺素能阻滞剂，在治疗中的作用，我们打算获得运动耐量试验，心电图，超声心动图在20名儿童治疗前，后4个月和6个月的维持治疗，并再次拉贝洛尔治疗后2周已经停止。 本研究的意义在于为儿童慢性CHF的治疗开发新方法的潜力。 在这种情况下使用拉贝洛尔有可能改善心脏功能，提高生活质量，延长生存期，降低医疗费用，推迟或排除心脏移植的需要。