EFFICACY OF INACTIVATED INFLUENZA VACCINE IN HOSPITAL STAFF

灭活流感疫苗对医院工作人员的功效

• 批准号: 6114373
• 负责人: MARK C STEINHOFF
• 金额: $ 2.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114373
• 关键词: clinical research; disease /disorder prevention /control; drug screening /evaluation; hospital personnel; human subject; human therapy evaluation; influenza vaccines; outcomes research; serology /serodiagnosis; tissue /cell culture

This study was undertaken to determine the clinical efficacy of trivalent inactivated influenza vaccine in the prevention of influenza infection and illness in young, healthy, hospital staff, and to determine the extent of reduction in absenteeism in this group as a result of receiving the vaccine. This is the third winter we have undertaken a study of the efficacy of the influenza vaccine in hospital staff. We enrolled a total of 156 adults in our study, 60 males and 96 females. Blood was drawn from each subject at the time of enrollment and again one month later. We began intensive surveillance on December 22, 1994 when the influenza epidemic appeared to start, telephoning each subject weekly to inquire about flu- like illness. Throat cultures were obtained on a total of 47 of the subjects who developed symptoms consistent with influenza. We continued surveillance for fourteen weeks, ending March 29, 1997 when sporadic febrile flu-like illnesses appeared to be diminishing in house officers. A final blood sample was obtained from all study subjects one month later. We attained 99% follow-up. We therefore had a total of 15288 days of observation of the house officers. The serological data is expected from the laboratory soon and is not available for this report. The results of this study thus far have been largely inconclusive. The first year the entire United States had a very mild influenza season. This second year other parts of the United States experienced a rather severe influenza season but Baltimore and most of Maryland had very little influenza reported. We await the serological data from the third winter.

本研究旨在确定 三价流感灭活疫苗在预防流感中的作用 感染和疾病的年轻，健康，医院工作人员， 确定该组缺勤率的减少程度， 接种疫苗的结果。 这是第三个冬天，我们已经进行了一项研究的有效性， 流感疫苗在医院工作人员。 我们总共招募了156名 在我们的研究中，有60名男性和96名女性。 从每个人身上抽取血液 受试者在入组时和一个月后再次接受检查。 我们开始 1994年12月22日流感大流行时， 似乎开始了，每周给每个受试者打电话询问流感情况， 就像生病一样。 共获得47例患者的咽部培养物。 出现流感症状的受试者。 我们继续 监测14周，1997年3月29日结束， 内务部官员的发热性流感样疾病似乎正在减少。 一个月后从所有研究对象中获得最终血液样本 后 随访率达到99%。 因此，我们总共有15288个 内务部官员的观察日。 血清学数据是 预计很快将从实验室获得，本报告无法获得。 到目前为止，这项研究的结果基本上还没有定论。 的 第一年，整个美国有一个非常温和的流感季节。 第二年，美国其他地区经历了一场相当大的 严重的流感季节，但巴尔的摩和大部分马里兰州有非常 小流感报告 我们在等第三批的血清学数据 冬天