IMAGING CENTRAL SEROTONIN RECEPTORS (5HT2) WITH C MDL 100907--PETT SCAN

测定DAE和DA浪涌对DA定量的影响 受体密度使用NMSP和RAC。使用苯丙胺(AMP)和 利血平(RES)分别增加或减少DAE，我们 会扰乱地区检察官系统。然后我们将衡量这些措施的影响 对DA D2受体的扰动(“类D2”)。 研究进展是研究内源性多巴胺对 用[11C]拉氯普利定量测定绝对受体密度Bmax 和[11C]NMSP。到目前为止，我们已经成功地完成了八个正常 受试者和四名精神分裂症患者的两次Bmax测量 没有安非他明也有安非他明。由于每个BMAX测量都需要 高和低比活度[11C]拉氯普利，每个受试者都收到了 在1-2周内进行四次正电子发射计算机断层扫描。这在逻辑上是一种 复杂的程序，因为在患者的情况下，他们必须 在每一对PET扫描之间不含药物，每一对都携带 只有一天的时间。这通常需要住院治疗。 约翰斯·霍普金斯大学的临床研究部。在某些情况下，用于临床 原因，有必要将受试者输入两次正电子发射计算机断层扫描 仅限协议，具有两个高比活度[11C]拉氯普利研究 在同一天没有使用安非他明和使用苯丙胺。这已经发生在 到目前为止招募的六名患者中的一名。 安非他明的作用是使观察到的Bmax下降。这个 精神分裂症患者的Bmax平均下降更大(2至3倍) 但在患者和正常人中，这种差异非常大。用方法 改进，更多的子分型和扩大样本这些结果可能 达到统计学意义。

To measure the effect of DAe and the DA surge on the quantitation of DA receptor density using NMSP and RAC. Using amphetamine (AMP) and reserpine (RES), which, respectively, increases or decreases DAe, we will perturb the DA system. We will then measure the effects of these perturbations on DA D2 receptors ("D2-like"). Progress is to examine the effects of endogenous dopamine on the quantification of absolute receptor density Bmax with [11C]raclopride and [11C]NMSP. To date, we have successfully completed eight normal subjects and four schizophrenic patients with two measurements of Bmax without and with amphetamine. Since each Bmax measurement requires both high and low specific activity [11C]raclopride, each subject received four PET scans over a period of 1-2 weeks. This is logistically a complex procedure, since in the case of the patients, they must remain drug-free between the pairs of PET scans, each pair of which are carried out on a single day. This has often required hospitalization in the Clinical Research Unit at Johns Hopkins. In some cases, for clinical reasons, it has been necessary to enter subjects into a two PET scan protocol only, with two high specific activity [11C]raclopride studies without and with amphetamine during the same day. This has occurred in one of the six patients recruited so far. The effect of amphetamine is to cause a fall in the observed Bmax. The average fall in Bmax is greater in schizophrenic patients (2 to 3 fold) but the variance is very large in patients and normals. With methods refinement, more subtyping and expanded samples these results may achieve statistical significance.