Establishment of a cell culture facility at Biogelx for the in-house validation and testing of Biogelx hydrogels

在 Biogelx 建立细胞培养设施，用于 Biogelx 水凝胶的内部验证和测试

• 批准号: MR/W004011/1
• 负责人: Fiona Murphy
• 金额: $ 5.78万
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW004011%2F1
• 关键词: Establishment; cell; culture; facility; Biogelx

Biogelx develops and produces materials that mimic the internal environment of the body. These new materials support the growth of cells outside the body in a laboratory environment under more realistic conditions than traditional methods where cells are grown on plastic or glass. Using the Biogelx material allows researchers to study the cells response to test substances such as drugs or toxic agents under conditions that are more similar to the natural environment of the body which in certain circumstances can be used as a replacement to animal testing.The Biogelx team is largely made up of scientists with a background in chemistry who specialize in the development of new materials. To improve their product and expand the services they offer to clients Biogelx need a laboratory facility suitable for growing cells. To set-up a laboratory to grow cells they require the knowledge of a scientist with a biology background who has expertise in this area. This will ensure tests carried out on cells grown on the Biogelx material in the new laboratory facility will meet the appropriate standards and generate reliable results.The secondee, Dr Fiona Murphy, has over 10 years' experience working as a biologist and carrying out both animal testing and experiments on cells grown in laboratory conditions. She is passionate about developing new approaches to conducting research which will reduce the numbers of animals used in biomedical testing while still providing reliable results. The secondment with Biogelx provides Dr Murphy the opportunity to use her experience working as a biologist in a University laboratory to guide the establishment of the biology facility at Biogelx, giving her an insight into working in a commercial laboratory environment. In a series of test-runs of the new facility Dr Murphy will grow cells using the Biogelx platform to ensure the facility is operational up to the appropriate standards. These test experiments will also produce some preliminary results important for Dr Murphy's own research goals.The partnership between Biogelx and Dr Murphy from Heriot-Watt University will help the company to expand and grow and also increase the future career mobility of Dr Murphy through experience gained working in a commercial lab environment.

Biogelx开发和生产模拟人体内部环境的材料。这些新材料支持细胞在实验室环境中在体外生长，比传统的细胞在塑料或玻璃上生长的方法更现实。使用Biogelx材料，研究人员可以在更接近人体自然环境的条件下研究细胞对药物或有毒物质的反应，在某些情况下可以替代动物试验。Biogelx团队主要由具有化学背景的科学家组成，他们专门从事新材料的开发。为了改进他们的产品和扩大他们为客户提供的服务，Biogelx需要一个适合培养细胞的实验室设施。为了建立一个实验室来培养细胞，他们需要一个具有生物学背景的科学家的知识，他在这一领域有专业知识。这将确保在新的实验室设施中对在Biogelx材料上生长的细胞进行的测试符合适当的标准，并产生可靠的结果。借调人员Fiona Murphy博士拥有超过10年的生物学家工作经验，并在实验室条件下进行动物测试和细胞生长实验。她热衷于开发新的方法来进行研究，这将减少生物医学测试中使用的动物数量，同时仍然提供可靠的结果。与Biogelx借调提供墨菲博士的机会，利用她的经验，作为一个生物学家在大学实验室指导在Biogelx生物设施的建立，让她深入了解在商业实验室环境中工作。在新设施的一系列测试运行中，墨菲博士将使用Biogelx平台培养细胞，以确保该设施的运行符合适当的标准。这些测试实验也将产生一些对Murphy博士自己的研究目标很重要的初步结果。Biogelx和来自Heriot-Watt大学的Murphy博士之间的合作伙伴关系将帮助公司扩大和发展，并通过在商业实验室环境中获得的经验增加Murphy博士未来的职业流动性。