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SAFETY, TOLERANCE, PHARMACOKINETICS, AND ANTIVIRAL ACTIVITY OF PMPA IN HIV

SAFETY, TOLERANCE, PHARMACOKINETICS, AND ANTIVIRAL ACTIVITY OF PMPA IN HIV
PMPA 在 HIV 中的安全性、耐受性、药代动力学和抗病毒活性
批准号：
6115494
负责人：
STEVEN Grant DEEKS
金额：
$3.1万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115494
关键词：
AIDS therapy HIV infections adenine analog antiAIDS agent clinical research clinical trial phase I drug screening /evaluation helper T lymphocyte human subject human therapy evaluation pharmacokinetics phosphonate prodrugs

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中文摘要
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英文摘要
The purpose of this study is to evaluate the safety and pharmacokinetics of single and multiple doses of PMPA pro-drug administered orally to HIV- infected patients and to evaluate the anti-HIV activity of PMPA pro-drug, as demonstrated by increases in CD4 cell counts and decreases in HIV RNA, when administered orally as a single dose and daily for four weeks to HIV- infected patients with CD4 cell counts >200 cells/mm3.
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