The lung in HIV disease

HIV疾病中的肺部

• 批准号: 6115247
• 负责人: ELIZABETH A RICH
• 金额: $ 1.92万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115247
• 关键词: AIDS; HIV infections; alveolar macrophages; bronchoscopy; cellular pathology; clinical research; diagnostic respiratory lavage; host organism interaction; human immunodeficiency virus; human subject; microorganism immunology; virus replication

The overall goals of this project are to examine the functions of alveolar macrophages from a spectrum of HIV infected patients and to quantitate the level of HIV in these cells and to examine determinants of replication of HIV in alveolar macrophages and the mechanisms underlying the functional consequences of HIV infection in macrophages. Bronchoscopies are performed on the GCRC to obtain cells used in this study. One substudy is to define the natural history of lymphocytic alveolitis (LAL) in a longitudinal study of HIV-infected subjects by examining the phenotype and viral load in bronchoalveolar cells versus blood mononuclear cells and selected functions that could impact on the pathogenesis of LAL. In this longitudinal yearly analysis of 20 asymptomatic HIV-infected subjects with no previous history of pulmonary disease, subjects have 2 visits to the GCRC: one for questionnaire, CXR, and PFTs and the second at 1 or 2 weeks later for lavage and venipuncture. Ongoing cross-sectional studies of HIV infected versus healthy controls will continue.

该项目的总体目标是检查一系列 HIV 感染患者的肺泡巨噬细胞的功能，定量这些细胞中的 HIV 水平，并检查肺泡巨噬细胞中 HIV 复制的决定因素以及巨噬细胞中 HIV 感染功能后果的机制。 对 GCRC 进行支气管镜检查以获得本研究中使用的细胞。其中一项子研究是通过检查支气管肺泡细胞与血液单核细胞的表型和病毒载量以及可能影响 LAL 发病机制的选定功能，在 HIV 感染者的纵向研究中定义淋巴细胞性肺泡炎 (LAL) 的自然史。在这项对 20 名既往无肺部疾病史的无症状 HIV 感染者的纵向年度分析中，受试者两次前往 GCRC：一次进行问卷调查、CXR 和 PFT，第二次在 1 或 2 周后进行灌洗和静脉穿刺。 正在进行的艾滋病毒感染者与健康对照的横断面研究将继续进行。