儿童肾移植后的重组生长激素（NUTROPIN）-猫眼课题宝

儿童肾移植后的重组生长激素（NUTROPIN）

批准号：

6115317

负责人：

IRA D DAVIS

金额：

$2.33万

依托单位：

CASE WESTERN RESERVE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/6115317

关键词：

body height child (0-11) child physical development clinical research cytokine gene expression homologous transplantation hormone therapy human subject human therapy evaluation kidney transplantation pathologic process pediatric pharmacology postoperative state somatotropin transplant rejection

中文摘要

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英文摘要

The specific aims are: 1) To determine if treatment of growth retarded renal transplant recipients with Nutropin will result in acceleration of growth velocity and improvement in standardized height (SDS). 2) To determine if treatment of pediatric renal transplant recipients with Nutropin will resuslt in the a) development or progression of acute allograft dysfunction or chronic rejection b) allograft injury c) changes of expression of cytokines c) the development of a significant increase in adverse events. We hypothesize that administration of recombinant human growth hormone (rhGH) to children following transplantation does not accelerate the progression to chronic allograft dysfunction.

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