DILTIAZEM-PREDNISONE INTERACTION IN RENAL TRANSPLANT PATIENTS

肾移植患者中地尔硫卓-泼尼松的相互作用

• 批准号: 6117966
• 负责人: ROBERT W STEINER
• 金额: $ 1.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117966
• 关键词: autologous transplantation; chemotherapy; clinical research; cytochrome P450; diltiazem; dosage; drug adverse effect; drug interactions; human subject; human therapy evaluation; kidney transplantation; prednisone

Investigate the possible role of diltiazem in potentiating the multiple effects of prednisone by decrasing its metabolism via the cytochrome P450 system. Enhance the understanding of the interaction between prednisone and diltiazem and generate data required to standardize dosing regimens which may reduce unwanted side effects.

研究地尔硫卓通过细胞色素P450系统降低泼尼松的代谢，从而增强其多重效应的可能作用。加强对泼尼松和地尔硫卓之间相互作用的了解，并产生标准化给药方案所需的数据，这可能会减少不想要的副作用。