ACTG 341: PATHOGENESIS OF MAC DISEASE IN ADVANCED HIV 1 & HAART IMPAC

ACTG 341：晚期 HIV 1 中 MAC 疾病的发病机制

• 批准号: 6265120
• 负责人: MITCHELL GOLDMAN
• 金额: $ 0.04万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265120
• 关键词: AIDS; AIDS /HIV test; AIDS therapy; Mycobacterium avium; Mycobacterium intracellulare; antiAIDS agent; biopsy; bone marrow exam; clinical research; clinical trial phase I; combination chemotherapy; human subject; human therapy evaluation; immunopathology; microorganism disease chemotherapy; opportunistic infections; tissue /cell culture; tuberculosis

To determine if tissue infection with MAC occurs prior to sustained bacteremia by obtaining bone marrow biopsies and blood for quantitative cultures from subjects at high risk for DMAC. To examine the relatioship between immune dysregulation and MAC disease by identifying immune profiles correlated with risk for MAC disease. To determine whether the abnormalities in immune cell populations and functions found in MAC- infected subjects and in asymptomatic subjects with low CD4+ counts can be reversed by HAART. To evaluate the relationship between changes in HIV RNA levels after HAART and changes in relevant immune parameters. To evaluate the relationships between baseline plasma HIV-1 RNA levels, relevant immune function abnormalities, and MAC infection status. To evaluate the diagnostic utility of rapid and potentially more sensitive new MAC detection methods by correlation with quantitative cultures of blood and bone marrow. To examine the incidence of intestinal and respiratory colonization of subjects with DMAC and compare the strain identities and virulence properties of colonizing strain(s) with MAC isolate(s) obtained from blood and bone marrow.

通过获取DMAC高危受试者的骨髓活检和血液定量培养来确定组织感染MAC是否发生在持续菌血症之前。通过确定与MAC病风险相关的免疫谱，研究免疫失调与MAC病之间的关系。为了确定在MAC感染患者和低CD4+计数的无症状患者中发现的免疫细胞群体和功能异常是否可以通过HAART逆转。探讨HAART后HIV-RNA水平变化与相关免疫参数变化的关系。探讨基础血浆HIV-1RNA水平、相关免疫功能异常与MAC感染状态之间的关系。通过与血液和骨髓定量培养的相关性，评价快速和潜在更敏感的新的MAC检测方法的诊断价值。目的了解新城疫患者肠道和呼吸道定植情况，比较定植株(S)与血源和骨髓分离株(S)的菌株同源性和毒力特性。