双胞胎-猫眼课题宝

双胞胎

批准号：

6265123

负责人：

SEAN O'CONNOR

金额：

$0.04万

依托单位：

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-12-01 至 1999-11-30

来源：

https://reporter.nih.gov/project-details/6265123

关键词：

alcoholic beverage consumption alcoholism /alcohol abuse clinical research disease /disorder proneness /risk family genetics genetic susceptibility human subject intravenous administration pharmacokinetics twin /multiplet

中文摘要

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英文摘要

We hypothesize that genetic variations in acute responses to alcohol influence a person's drinking habits and risk for alcoholism. Hence, we predict that an individual's initial response and acute adaptation to alcohol are both correlated with familial history for alcoholism (FHA) and recent drinking history (RDH). We also postulate that manifestation of genetic influences may vary as a function of the concentration of brain's exposure to alcohol. We propose 3 projects to test our predictions. Each project employs the intravenous (iv) alcohol clamping method, shown in our recent studies to be capable of maintaining breath alcohol concentration (BrAC), and hence the brain's exposure to alcohol, at nearly constant, predeterminal levels over time.

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