AUTONOMIC AND HEMODYNAMIC RESPONSE IN SICK SINUS SYNDEOME

病态窦房结综合征的自主反应和血流动力学反应

• 批准号: 6117955
• 负责人: FABIO LEONELLI
• 金额: $ 1.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117955
• 关键词: analytical chemistry; autonomic disorder; biomedical facility; catecholamines; cooperative study; exercise; heart disorder; hemodynamics; syndrome

Agreement between GCRC Core Laboratory at UC San Diego and GCRC at University of Kentucky to perform catecholamine assay on samples sent to San Diego. Determine the potential role of autonomic dysfunction in sick sinus syndrome (SSS) by evaluating the autonomic system modulation of cardiovascular responses to tilt and isometric exercise in normal subjects and those with SSS. Determine the degree of cardiac abnormalities and their relationship to systolic function before, at 6 weeks and 3 months post-implant.

加州大学圣地亚哥分校的GCRC核心实验室与肯塔基州大学的GCRC达成协议，对送往圣地亚哥的样本进行儿茶酚胺含量测定。通过评估正常受试者和病态窦房结综合征（SSS）患者对倾斜和等长运动的心血管反应的自主神经系统调节，确定自主神经功能障碍在病态窦房结综合征（SSS）中的潜在作用。 确定植入前、植入后6周和3个月时心脏异常的程度及其与收缩功能的关系。