INFLUENCE OF HELICOBACTER PYLORI AND DUODENAL ULCER ON ENTEROCYTES

幽门螺杆菌和十二指肠溃疡对肠细胞的影响

• 批准号: 6117949
• 负责人: JON I ISENBERG
• 金额: $ 1.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117949
• 关键词: Helicobacter; acid base balance; clinical research; duodenal ulcer; duodenum; gastrointestinal absorption /transport; gastrointestinal epithelium; gastrointestinal infection; human subject

Determine acid-base transporters in duodenal enterocytes of healthy human volunteers, determine if a defect is present in acid-base transport and regulation of pHi in duodenal epithelia of patients with duodenal ulcer disease, and study the effect of eradication of helicobacter pylori on acid-base transport mechanisms in duodenal epithelia of patients with duodenal ulcer disease. Identify the cellular abnormalities in acid/base transport in patients with cystic fibrosis.

确定健康志愿者十二指肠肠上皮细胞中的酸碱转运蛋白，确定十二指肠溃疡病患者十二指肠上皮细胞中酸碱转运和pHi调节是否存在缺陷，并研究根除幽门螺杆菌对十二指肠溃疡病患者十二指肠上皮细胞中酸碱转运机制的影响。 确定囊性纤维化患者酸/碱转运的细胞异常。