PCO MEASUREMENT OF RAS PROTEIN IN PCOS

与正常女性相比，高胰岛素血症多囊卵巢综合征（PCOS）患者表现出更高的法尼化RAS蛋白表达。大鼠肉瘤（RAS）是一种细胞内蛋白，与细胞增生、肿瘤等增生状态有关。多囊卵巢的特点是卵巢增生性改变，如多发大囊肿形成、卵泡细胞增生、髓质间质增加、被膜增厚和全身肿大。多囊卵巢综合征患者也有高胰岛素血症。本研究希望确定法酰化RAS蛋白的表达是否与该疾病的临床特征相关。

Hyperinsulinemic patients with polycystic ovary syndrome (PCOS) exhibit a greater expression of farnesylated RAS protein compared to that of normal women. Rat sarcoma (RAS) is an intracellular protein which is associated with cellular proliferative states such as hyperplasia and neoplasia. In PCOS the ovary is characterized by proliferative changes such as multiple large cyst formation, theca cell hyperplasia, an increase in medullary stroma, a thickened capsule and general enlargement. PCOS patients are also hyperinsulinemic. This study wishes to determine whether the expression of farnesylated RAS protein is correlated to clinical features of this disorder.