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PCO MEASUREMENT OF RAS PROTEIN IN PCOS

PCO MEASUREMENT OF RAS PROTEIN IN PCOS
PCOS 中 RAS 蛋白的 PCO 测量
批准号：
6265182
负责人：
JEFFREY T CHANG
金额：
$1.15万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6265182
关键词：
cell proliferation cellular pathology clinical research farnesyl compound female gene expression graafian follicles guanine nucleotide binding protein human subject hyperinsulinism hyperplasia ovarian cysts polycystic ovary syndrome sarcoma

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英文摘要
Hyperinsulinemic patients with polycystic ovary syndrome (PCOS) exhibit a greater expression of farnesylated RAS protein compared to that of normal women. Rat sarcoma (RAS) is an intracellular protein which is associated with cellular proliferative states such as hyperplasia and neoplasia. In PCOS the ovary is characterized by proliferative changes such as multiple large cyst formation, theca cell hyperplasia, an increase in medullary stroma, a thickened capsule and general enlargement. PCOS patients are also hyperinsulinemic. This study wishes to determine whether the expression of farnesylated RAS protein is correlated to clinical features of this disorder.
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