Investigating the Effect of the Menstrual Cycle on Social Stress in Early Psychosis Through Ecological Momentary Assessment

通过生态瞬时评估研究月经周期对早期精神病社会压力的影响

• 批准号: MR/W015943/2
• 负责人: Thomas Reilly
• 金额: $ 27.57万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW015943%2F2
• 关键词: Investigating; Effect; Menstrual; Cycle; Social

Psychosis is a severe mental illness which has major costs both to society and to individuals affected. Relapses of psychosis are incredibly disruptive for patients' lives. For women who have psychosis, the time around their menstrual period carries a particularly high risk for relapse. Patient groups report that the menstrual cycle is an important topic for consideration but it has been relatively overlooked in research to date. The reasons why the menstrual cycle should affect women with psychosis are not clear but may relate to social stress. Response to stress, particularly in social situations, seems to be important in the development of psychosis. This is the case for people who have recently developed a psychotic illness as well as those who are at higher risk of psychosis. Response to stress also varies across the menstrual cycle, which could explain why psychosis seems to worsen around the time of menstruation. We will use a newly developed smartphone app, Social Mind to measure daily responses to stress. Smartphone apps offer a convenient way for participants to measure both the menstrual cycle and response to stress. They can also be used to monitor social withdrawal, measured through reduced movement. The app will use phone movement data to passively measure social withdrawal. The app will be used by participants to record their menstrual periods. Women who are either at risk of psychosis or who are experiencing their first episode of psychosis will be asked to complete these measures. For comparison, healthy women will complete the measures as well.We will analyse whether social stress and withdrawal are affected by the menstrual cycle. We will examine whether relapse of psychosis is more likely at certain times of the cycle and if stress influences it. We will compare differences between women who are experiencing psychosis, those at risk of psychosis and those not affected by mental health problems.It is hoped by understanding how the menstrual affects response to stress in psychosis, new targets for treatment will be identified. At present, all antipsychotic medications work in a similar way and have troublesome side-effects. Medications that stabilise hormonal fluctuations represent a completely different approach that could work for some women.

精神病是一种严重的精神疾病，对社会和受影响的个人都有重大损失。精神病的复发对病人的生活是难以置信的破坏。对于患有精神病的女性来说，月经期间复发的风险特别高。患者团体报告说，月经周期是一个重要的考虑因素，但它一直在研究中相对被忽视的日期。为什么月经周期会影响患有精神病的女性，原因尚不清楚，但可能与社会压力有关。对压力的反应，特别是在社会环境中，似乎在精神病的发展中很重要。对于最近患上精神病的人以及那些精神病风险较高的人来说，情况就是这样。对压力的反应在月经周期中也各不相同，这可以解释为什么精神病似乎在月经期间恶化。我们将使用新开发的智能手机应用程序Social Mind来测量日常对压力的反应。智能手机应用程序为参与者提供了一种方便的方式来测量月经周期和对压力的反应。它们也可以用来监测社交退缩，通过减少运动来衡量。该应用程序将使用手机移动数据来被动地测量社交退缩。参与者将使用该应用程序记录他们的月经期。将要求有精神病风险或正在经历首次精神病发作的妇女完成这些措施。作为比较，健康女性也会完成测试，分析社交压力和退缩是否受月经周期影响。我们将研究在月经周期的某些时间段精神病复发的可能性是否更大，以及压力是否会影响精神病复发。我们将比较正在经历精神病的女性，那些有精神病风险的女性和那些没有精神健康问题的女性之间的差异。希望通过了解月经如何影响精神病对压力的反应，将确定新的治疗目标。目前，所有的抗精神病药物都以类似的方式起作用，并有令人烦恼的副作用。稳定荷尔蒙波动的药物代表了一种完全不同的方法，可能对某些女性有效。

项目成果

Systematic review of the association between adverse life events and the onset and relapse of postpartum psychosis.

• DOI: 10.3389/fpsyt.2023.1154557
• 发表时间: 2023
• 期刊: FRONTIERS IN PSYCHIATRY
• 影响因子: 4.7
• 作者: Reilly, Thomas J.;Roberts, Emma;De La Bastida, Vanessa Charlotte Sagnay;McGuire, Philip;Dazzan, Paola;Cullen, Alexis E.
• 通讯作者: Cullen, Alexis E.

Intermittent selective serotonin reuptake inhibitors for premenstrual syndromes: A systematic review and meta-analysis of randomised trials.

• DOI: 10.1177/02698811221099645
• 发表时间: 2023-03
• 期刊: JOURNAL OF PSYCHOPHARMACOLOGY
• 影响因子: 4.1
• 作者: Reilly, Thomas J.;Wallman, Phoebe;Clark, Ivana;Knox, Clare-Louise;Craig, Michael C.;Taylor, David
• 通讯作者: Taylor, David

The prevalence of premenstrual dysphoric disorder: Systematic review and meta-analysis

经前焦虑障碍的患病率：系统回顾和荟萃分析

• DOI: 10.1016/j.jad.2024.01.066
• 发表时间: 2024
• 期刊: Journal of Affective Disorders
• 影响因子: 6.6
• 作者: Reilly T

A case series of premenstrual disorders presenting to the UK's National Female Hormone Clinic.

• DOI: 10.1192/bjb.2022.63
• 发表时间: 2023-10
• 期刊: BJPSYCH BULLETIN
• 影响因子: 2.6
• 作者: Reilly, Thomas J.;Knox, Clare-Louise;Marsh, Michael S.;Craig, Michael C.
• 通讯作者: Craig, Michael C.

Point of care assay for blood aripiprazole concentrations: development, validation and utility.

血液阿立哌唑浓度的护理点测定：开发、验证和实用性。

• DOI: 10.1192/bjp.2023.58
• 发表时间: 2023
• 期刊: the journal of mental science
• 作者: Atkins M