TYPE 2 DIABETES MELLITUS AND INSULIN SECRETION

2 型糖尿病和胰岛素分泌

• 批准号: 6265279
• 负责人: JOHN B HANKS
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265279
• 关键词: clinical research; family genetics; heterozygote; hormone biosynthesis; hormone regulation /control mechanism; human subject; insulin; noninsulin dependent diabetes mellitus; pancreatic islet function; pancreatic islets; point mutation; transcription factor

The hypothesis we are testing is that heterozygote status for IPF-1 mutation is associated with the development of early onset type 2 Diabetes Mellitus (MODY4) through an effect on the development and/or function of the insulin producing pancreatic beta cells. In this protocol, we plan to quantitate the insulin secretory defect in a family harboring a point mutation in the IPF-1 gene. Study ongoing.

我们正在测试的假设是，IPF-1突变的杂合子状态通过影响产生胰岛素的胰腺细胞的发育和/或功能与早发性2型糖尿病（MODY4）的发展有关。在这个方案中，我们计划在IPF-1基因中携带点突变的家族中量化胰岛素分泌缺陷。研究正在进行。