CRYSTAL STRUCTURE OF TRANSLATION INITIATION FACTOR (EIF 5A)

翻译起始因子的晶体结构 (EIF 5A)

• 批准号: 6119452
• 负责人: KYEONG-KYU KIM
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119452
• 关键词: biomaterials; neoplasm /cancer; proteins

Translation initiation factor 5A (eIF-5A) is the only protein which has the modified amino acid, hypusine (spermidine addition into the lysine residue) in nature. The modification of this lysine residue, which is located in the center of a very well conserved sequence region, into hypusine, is known to be very essential for the proliferation of the cell. For these reasons, eIF5a and its modification enzyme, deoxyhypusine synthases, are considered as the target proteins for the development of an antiproliferation drug. A recent study shows that eIF-5A acts as the cofactor of human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein.

翻译起始因子5A（translation initiation factor 5A，eIF-5A）是唯一一种 其具有修饰的氨基酸，羟腐胺赖氨酸（亚精胺添加到 赖氨酸残基）。 赖氨酸的修饰 残基，它位于一个非常保守的 序列区，转化为羟腐胺赖氨酸，已知对于 细胞的增殖。 由于这些原因，eIF 5a及其 修饰酶，脱氧羟腐胺赖氨酸脱氢酶，被认为是 用于开发抗增殖药物的靶蛋白。 一 最近的研究表明，eIF-5A作为人类的辅助因子， 免疫缺陷病毒1型（HIV-1）Rev反式激活蛋白。