CO CRYSTAL STRUCTURES OF HEPATITIS VIRUS 3C PROTEINS W/ PROTEINASE INHIBITORS

具有蛋白酶抑制剂的肝炎病毒 3C 蛋白的共晶体结构

• 批准号: 6119458
• 负责人: ERNST M BERGMANN
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119458
• 关键词: biomaterials; liver; pharmacology; virus

Positive-sense, single-stranded RNA viruses translate their RNA genome into large polyproteins which are subsequently proteolytically processed to yield the mature viral proteins. Hepatitis A virus expresses a single proteolytic activity which cleaves itself and all other gene products out of the single polyprotein which results from translation. Effective proteinase inhibitors of the enzymatic activity of the 3C proteinase prevent viral replication and have potential as antiviral drugs. The structure of the native 3C proteinase forms the basis for a long term project, aimed at understanding the catalytic mechanism and proteolytic specificity of the hepatitis A virus proteinase and with the ultimate goal of designing effective proteinase inhibitors with a potential as antiviral therapeutics.

阳性意义的单链RNA病毒翻译它们的RNA