SH3 DOMAIN COMPLEXED TO NON NATURAL LIGAND
SH3 DOMAIN COMPLEXED TO NON NATURAL LIGAND
与非天然配体复合的 SH3 结构域
批准号：
6119461
负责人：
JACK T NGUYEN
金额：
$0.0万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-03-01 至 2000-04-14
中文摘要
翻译
SH3结构域是在信号中发现的小的模结构域
英文摘要
SH3 domains are small, modular domains found in signal
transduction molecules and are believed to mediate the formation of
protein-protein complexes. We have designed peptide-based,
non-natural ligands to the SH3 domain from Sem5. We have the
structures of two different ligand-SH3 complexes solved to 2.2 E.
However, as the ligands contain unnatural amino acids with unusual
sidechains, we would like to obtain better resolution in order to
verify sidechain geometries and interactions.
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