STRUCTURE DETERMINATION OF GLYCOHORMONES & OLIGOSACCHARIDE RELEASING ENZYMES

卵泡刺激素(FSH)是一种糖蛋白激素， 在生育方面起着重要作用。人体的结晶学研究 促性腺激素释放激素的目标是确定与 通过相互关联受体结合和信号转导 具有定点突变结果的结构数据。远藤A是 一种内切糖苷酶，一种从 糖蛋白，这是独特的，因为它的转糖基化 属性。Endo A的结构表征将提供 在酶的功能方面的重要见解将导致 酶作为生产工具的进一步开发 新糖偶联物。

Follicle stimulating hormone (FSH) is a glycoprotein hormone that plays a major role in fertility. Crystallographic studies of human FSH are aimed at identifying molecular features that are responsible for receptor binding and signal transduction by correlating the structural data with results of site directed mutagenesis. Endo A is an endoglycosidase, an enzyme that releases oligosaccharides from glycoproteins, that is unique because of its transglycosylation properties. Structural characterization of Endo A will provide important insights in the function of the enzyme that will lead to further development of the enzyme as a tool for the production of neoglycoconjugates.