Development of a PET detection system prototype with depth of interaction capability

开发具有深度交互能力的PET检测系统原型

• 批准号: nhmrc : 162722
• 负责人: Prof Anatoly Rozenfeld
• 金额: $ 24.07万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-pet-detection-interaction-capability/78391
• 关键词: Development; PET; detection; system; prototype

This development project invovles the development of a slim-line Positron Emission Tomogrphy (PET) detection sub-module, the crucial component of PET scanners, that is small and extremely flexible. It is planned to utilize this module in the design of customized new commercial PET scanners ideal for diagnosing human brain and breast disorders. The development will proceed in collaboration with Insight Oceania-ADAC, Sydney. Insight Oceania-ADAC are very excited by the potential applications and future markets (Australia and overseas) of the newly developing PET detection sub-modules for dedicated PET scanners. Positron Emission Tomography (PET) is a functional imaging tool, which is able to quantify physiological and biochemical processes in vivo, using short-lived cyclotron-produced radiotracers. PET is emerging as an extremely important diagnostic procedure used in the early detection of cancers, neurological diseases and as an aid in treatment monitoring and drug development. The unique advantage of PET over anatomical imaging techniques, such as X-ray CT and MRI, arises from its ability to measure changes in tumour biology, at the molecular level, prior to anatomical changes in involved tissues, using trace amounts of a radiolabelled compound (radiotracer). The full potential of PET however, is not being completely utilized due to constraints within the current designs of PET scanners. When used to its full potential PET, in principle, would be an excellent diagnostic and treatment monitoring tool for breast cancer, brain tumours and other neurological conditions such as epilepsy, Alzheimer's, Parkinson's disease, post stress disorder, dementia, and depression. Lack of flexibility in current PET scanner designs to date has meant that no commercial human brain or breast imaging scanners exist. Pilot project data proved the feasibility of our new flexible PET detection module design.

该开发项目包括开发一种细线正电子发射断层扫描(PET)检测子模块，这是PET扫描仪的关键组件，它体积小，非常灵活。该公司计划将该模块用于设计定制的新型商用PET扫描仪，该扫描仪非常适合诊断人类大脑和乳房疾病。开发将与悉尼大洋洲洞察-ADAC合作进行。Insight大洋洲-ADAC对新开发的用于专用PET扫描仪的PET检测子模块的潜在应用和未来市场(澳大利亚和海外)感到非常兴奋。正电子发射断层扫描(PET)是一种功能成像工具，它能够利用回旋加速器生产的短期放射性示踪剂对体内的生理和生化过程进行量化。PET正在成为一种极其重要的诊断程序，用于癌症、神经系统疾病的早期检测，并作为治疗监测和药物开发的辅助工具。与X-射线、CT和MRI等解剖成像技术相比，正电子发射计算机断层扫描的独特优势在于，它能够利用微量的放射性标记化合物(放射性示踪剂)，在相关组织发生解剖变化之前，在分子水平上测量肿瘤生物学的变化。然而，由于目前PET扫描仪设计的限制，PET的全部潜力并未得到充分利用。当PET发挥其全部潜力时，原则上将成为乳腺癌、脑瘤和其他神经疾病(如癫痫、阿尔茨海默氏症、帕金森氏症、应激后障碍、痴呆症和抑郁症)的优秀诊断和治疗监测工具。到目前为止，目前的PET扫描仪设计缺乏灵活性，这意味着不存在商用人脑或乳房成像扫描仪。中试项目数据证明了我们设计的新型柔性PET检测模块的可行性。