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DOES MYOSIN HAVE CO EXISTING CONFORMATIONS?

DOES MYOSIN HAVE CO EXISTING CONFORMATIONS?
肌球蛋白是否具有共存的构象？
批准号：
6120273
负责人：
MANUEL F MORALES
金额：
$0.11万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-03-01 至 2000-02-29
来源：
https://reporter.nih.gov/project-details/6120273
关键词：
AIDS biological products biomedical resource clinical research endocrine gland /system enzymes hormones immunology infection inflammation lymphatic system microorganism plants spectrometry structural biology virus women's health

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英文摘要
N[4-(Trifluoromethyl)phenylliodacetamide, "TPI", has been synthesized, and it is sought to know its elemental composition. This composition, together with its 1-H and 19-F spectra, will be used to confirm the structure of TPI. Authentic TPI will be reacted with Cys-707 of myosin, thus endowing myosin with an NMR (19-F) "reporter" group. Hopefully this group will report conformational transitions thought to occur in myosin in the Oo-10oC range of temperature. More accurate positioning (better specificity) will be acheived by a corresponding (14-C) iodoacetamide synthesis.
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