MICA: [18F]LW223: a superior TSPO PET radiotracer for a clinical breakthrough to detect regional tissue inflammation

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This project will study the utility of a new tool for scanning patients that will allow doctors to better understand how diseases start and evolve as well as how to better treat their patients. This new tool is based on a highly specialized scanning technique called positron emission tomography or PET. This technique allows for the study of different processes happening inside the human body by injecting a small amount of a substance into patients. That substance is called a radiotracer and after injection it travels in the patients' blood stream, reaches the target inside the body and emits a signal that can be detected outside the patients' body using a very sensitive camera. Our new radiotracer, that we named LW223, was designed so it can target inflammation inside the body. In this project we will be tracking LW223 signal inside the human body over time. We will do those tracking studies both in healthy conditions and post-heart attack to confirm this signal represents tissue inflammation.