MICA: [18F]LW223: a superior TSPO PET radiotracer for a clinical breakthrough to detect regional tissue inflammation

MICA：[18F]LW223：一种卓越的 TSPO PET 放射性示踪剂，在检测局部组织炎症方面取得了临床突破

• 批准号: MR/W029464/1
• 负责人: Adriana Tavares
• 金额: $ 246.09万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW029464%2F1
• 关键词: MICA; 18F; LW223; superior; TSPO

This project will study the utility of a new tool for scanning patients that will allow doctors to better understand how diseases start and evolve as well as how to better treat their patients. This new tool is based on a highly specialized scanning technique called positron emission tomography or PET. This technique allows for the study of different processes happening inside the human body by injecting a small amount of a substance into patients. That substance is called a radiotracer and after injection it travels in the patients' blood stream, reaches the target inside the body and emits a signal that can be detected outside the patients' body using a very sensitive camera. Our new radiotracer, that we named LW223, was designed so it can target inflammation inside the body. In this project we will be tracking LW223 signal inside the human body over time. We will do those tracking studies both in healthy conditions and post-heart attack to confirm this signal represents tissue inflammation.

该项目将研究一种用于扫描患者的新工具的实用性，这将使医生能够更好地了解疾病如何开始和演变，以及如何更好地治疗患者。这种新工具是基于一种高度专业化的扫描技术，称为正电子发射断层扫描或PET。这种技术允许通过向患者注射少量物质来研究人体内发生的不同过程。这种物质被称为放射性示踪剂，注射后，它在患者的血流中移动，到达体内的目标，并发出信号，可以在患者体外使用非常灵敏的相机检测到。我们命名为LW223的新放射性示踪剂被设计成可以靶向体内的炎症。在这个项目中，我们将随着时间的推移跟踪人体内的LW223信号。我们将在健康状况和心脏病发作后进行这些跟踪研究，以确认这种信号代表组织炎症。