FLUID DYNAMICS OF SHUNT FLOWS IN PEDIATRIC CARDIOLOGY: SEPTAL DEFECT

儿科心脏病学中分流的流体动力学：间隔缺损

• 批准号: 6122396
• 负责人: EDWARD G CAPE
• 金额: --
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122396
• 关键词: bioengineering /biomedical engineering; biological products; biomedical resource; cardiovascular system; child (0-11); computers; congenital disorders; female; male

Ventricular septal defects are present in approximately 30% of all cases of congenital heart disease. A VSD is a variably sized hole in the septum which divides the left and right ventricles of the heart. If a VSD is present, the pressure difference between ventricles forces part of the exiting left ventricular blood through the defect into the right ventricle, and once again to the pulmonary circulation. Such a condition results in decreased mechanical efficiency of the left heart. For moderate to large VSD's, the volume and pressure on the right side of the heart increase which can result in pulmonary vascular disease(hypertrophic occlusion of the pulmonary arterioles). The study will focus on the fundamental fluid mechanics of VSD's and accomplish two specific aims as follows. (1) To understand the proximal(left ventricular) flow field converging in to the VSD and the interaction between converging flow and crossflowing streams due to systolic ejection. (2) To understand the distal(right ventricular) jet flow field and its interaction with crossflowing streams due to systolic outflow. These aims will be accomplished using computer simulations on the Cray Y-MP C90 using Finite Difference Techniques. The basic understanding will allow the applicant to build on previous theoretical and experimental work in the setting of valvular insufficiency to derive potential VSD quantification techniques.

约30%的患者存在室间隔缺陷。 先天性心脏病的病例。VSD是一个大小可变的洞 分隔心脏左、右室的隔膜。 如果存在室性心动过速，两个心室之间的压差会迫使 部分流出的左心室血通过缺损处进入 右心室，再一次进入肺循环。这样的一个 状态导致左侧机械效率降低 心。对于中到大型VSD，容量和压力 右侧心脏增大，可导致肺 血管疾病(肺小动脉肥厚性闭塞)。 这项研究将集中在VSD的基本流体力学和 实现以下两个具体目标。(1)了解 近端(左心室)流场汇聚到室间隔缺损和 汇流与横流之间的相互作用 收缩期射血。(2)了解远端(右室) 喷流场及其与横流的相互作用 收缩期流出量。这些目标将使用计算机来实现 用有限差分技术对Cray Y-MP C90进行模拟 基本理解将允许申请者在以前的基础上继续发展 瓣膜置入的理论与实验研究 不足以得出潜在的室间隔缺损量化技术。