DEVELOPMENT OF SURFACE COIL RESONATORS FOR IN VIVO L BAND

体内 L 波段表面线圈谐振器的开发

• 批准号: 6206503
• 负责人: HIROSHI HIRATA
• 金额: $ 0.61万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6206503
• 关键词: Mammalia; bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource; gas; nuclear magnetic resonance spectroscopy; technology /technique

One of the strengths of oxygen sensitive EPR materials, is that they can be implanted into tissues for use in monitoring oxygenation over days to weeks. One difficulty with such long term experiments (or with implanting in patients), is that the precise local of the material is not immediately evident. In order to overcome this problem, we are assessing the use of non-invasive MR imaging as a method of localizing the EPR implants. All of the EPR materials studied to date have a magnetic susceptability which makes them appear dark on gradient echo MR images. Conversely, with imaging protocols which minimize susceptability effects (short TE spin echo sequences), the material is minimally visible. In this project, we are optimizing imaging paramaters for either increasing or reducing the visibility of EPR materials in non-invasive MR exams.

氧敏EPR材料的优点之一是， 它们可以植入组织中用于监测氧合 几天到几周。 此类长期实验的一个困难是 (or与植入患者），是准确的局部 材料并不立即明显。 为了克服这个 问题，我们正在评估使用非侵入性磁共振成像作为一种 定位EPR植入物的方法。 所有EPR材料 迄今为止的研究表明，它们具有磁性， 在梯度回波MR图像上变暗。 相反，通过成像协议， 其最小化可重复性效应（短TE自旋回波序列）， 材料是最小可见的。 在这个项目中，我们正在优化 用于增加或减少的可见度的成像参数 非侵入性MR检查中的EPR材料。