TRANSFER OF TECHNOLOGY FOR DEVELOPMENT & APPLICATIONS OF IN VIVO EPR

一段时间以来，人们已经知道， 大脑的氧分压不同 也知道不同的 大脑的宏观区域表现出对 缺氧/缺血。 然而，目前尚不清楚， 氧合与对缺氧/缺血的耐受性相关。 我们 使用植入特定部位的LiPc评估局部脑pO 2， 麻醉大鼠。 然后使动物经受分级缺氧 议定书 比较大脑中的常氧和缺氧pO 2值。 被评估的区域是皮层、海马和基底神经节， 已知具有不同低氧耐受性的区域。

It has been known for some time that different regions of the brain have different oxygen tensions. It is also known that different macroscopic regions of the brain exhibit differing tolerances to hypoxia/ischemia. However, it is not known if the variation in oxygenation correlates with tolerance to hypoxia/ishemia. We are assessing regional brain pO2 using LiPc implanted at specific sites in anesthetized rats. The animal is then subjected to a graded hypoxia protocol. Normoxic and hypoxic pO2 values in the brain are compared. The regions being assessed are cortex, hippocampus and basal ganglia, regions which are known to have differing hypoxia tolerances.