PARAMAGNETIC OXYGEN SENSITIVE MATERIALS TO ASSESS TUMOR PO2 AT MULTIPLE SITES

BOLD成像已被用于监测大脑中的氧合作用 利用脱氧血红蛋白具有顺磁性这一事实 易感等脱氧血红蛋白含量的变化可 使用磁共振成像进行可视化。这一现象构成了 认知或功能性磁共振成像领域。此外，这一点 测量提供了一种快速的、空间选择性的评估方法 大脑对急性缺氧的反应。我们正在调查 BOLD成像与脱氧血红蛋白变化的关系 用EPR血氧测定仪测定脑氧分压。组织之间的关系 PO2值和平均血红蛋白饱和度不容易预测 而且必须加以衡量。与非侵入性EPR相结合 血氧仪和磁共振成像，我们希望校准大胆的反应在 活脑，决定大脑对功能的局部敏感度 成像和识别大脑反应的空间异质性 急性缺氧。

BOLD imaging has been used to monitor oxygenation in brain by capitalizing on the fact that deoxyhemoglobin has a paramagnetic susceptability and so changes in deoxyhemoglobin content can be visualized using MR imaging. This phenomenon forms the core of the field of cognative, or functional MR imaging. In addition, this measurement provides a rapid, spatially selective method of assessing the brain's response to acute hypoxia. We are investigating the relationships between changes in deoxyhemoglobin using BOLD imaging and brain pO2 using EPR oximetry. The relationships between tissue pO2 values and averaged hemoglobin saturation are not easily predicted and must be measured. With the combination of "non-invasive" EPR oximetry and MR imaging, we hope to calibrate the BOLD response in living brain, determine the regional senstivity of brain to functional imaging and identify spatial heterogeneity in the brain's response to acute hypoxia.