PRINCIPAL NIH RESEARCH RESOURCE X RAY BEAMLINE AT NSLS: WIGGLER BEAMLINE X25

多年来，X25 可以说一直是最受欢迎的 美国的光束线。 事实是，大分子 晶体学测量最近在以下领域的竞争非常激烈 使用该设施说明了可能结果的重要性， 以及实验者制备的质量。 然而， 部分原因是在光束线上赢得时间的用户已经 来自美国最有经验的团体，部分原因是 可供教学的人员太少 在参观者的监督下，光束线运行在一个相对 PX 的原始模式：不合格的检测器、不符合标准的软件 超出了简单的操作范围，几乎没有经验丰富的帮助 超出初始操作训练的晶体学家 光束线。 因此，我们将着手这项技术开发 建立设备、软件和方法的项目不仅 将增强我们进行不可能的测量的能力 NSLS dip ole bearrilines，而且绝对会是最 有效利用这一宝贵资源。 在某种程度上，项目1。 1 和 1.2 是其中的一部分 - 软件和硬件的开发。 X25 成为所有这些发展必须到来的焦点 共同实现最高目标并解决最困难的问题 生物学问题。

For several years X25 arguably has been the most sought-after beamline in the United States. The fact that macromolecular crystallographic measurements have competed so well recently for access to this facility speaks to the importance of the likely result, and the quality of preparations made by the experimenters. However, partially because the users who win time on the beamline have been from the most experienced groups in the U.S., and partially because there has been too little personnel available for teaching and supervision of visitors, the beamline has run in a relatively primitive mode for PX: substandard detectors, software that does not go beyond simple operations, and little assistance from experienced crystallographers beyond initial training in operation of the beamline. Therefore, we will embark on this technological development project to establish apparatus, software, and methods that not only will enhance our ability to make measurements that are impossible on NSLS dip ole bearrilines, but also will make absolutely the most efficient use of this precious resource. To some extent, projects 1. 1 and 1.2 are a part of this - development of software and hardware. X25 becomes the focus point where all of these developments must come together to achieve the highest goals and to solve the most difficult biological problems.