PRINCIPAL NIH RESEARCH RESOURCE X RAY BEAMLINE AT NSLS: WIGGLER BEAMLINE X25

NIH 主要研究资源 NSLS 的 X 射线束线：WIGGLER BEAMLINE X25

• 批准号: 6123513
• 负责人: LONNY E BERMAN
• 金额: $ 8.31万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-02 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123513
• 关键词: bioimaging /biomedical imaging; biological products; biomedical equipment development; biomedical resource; radiography; radiology; structural biology; technology /technique

For several years X25 arguably has been the most sought-after beamline in the United States. The fact that macromolecular crystallographic measurements have competed so well recently for access to this facility speaks to the importance of the likely result, and the quality of preparations made by the experimenters. However, partially because the users who win time on the beamline have been from the most experienced groups in the U.S., and partially because there has been too little personnel available for teaching and supervision of visitors, the beamline has run in a relatively primitive mode for PX: substandard detectors, software that does not go beyond simple operations, and little assistance from experienced crystallographers beyond initial training in operation of the beamline. Therefore, we will embark on this technological development project to establish apparatus, software, and methods that not only will enhance our ability to make measurements that are impossible on NSLS dip ole bearrilines, but also will make absolutely the most efficient use of this precious resource. To some extent, projects 1. 1 and 1.2 are a part of this - development of software and hardware. X25 becomes the focus point where all of these developments must come together to achieve the highest goals and to solve the most difficult biological problems.

几年来，X25可以说是最受欢迎的 beamline在美国 事实上，大分子 晶体学测量最近竞争如此激烈， 能够使用这种设施说明了可能结果的重要性， 以及实验者所做准备的质量。 然而，在这方面， 部分是因为在光束线上赢得时间的用户已经被 来自美国最有经验的团体，部分原因是 可供教学的人员太少， 监督游客，光束线已运行在一个相对 PX的原始模式：不合格的探测器，不 超越简单的操作，经验丰富的帮助很少 晶体学家除了在操作中的初始培训外， 光束线 因此，我们将着手进行这项技术开发 建立设备、软件和方法的项目， 将增强我们的测量能力， NSLS浸ole bearrilines，但也将使绝对最 有效利用这一宝贵资源。 在某种程度上，1。 1和1.2是其中的一部分-软件和硬件的开发。 X25成为所有这些发展必须到来的焦点 共同实现最高目标，解决最困难的问题。 生物问题。