SIGNAL TRANSDUCTION MECHANISMS AND CELL FUNCTION

描述(申请人描述)：这个项目的目的是培训新一代信号转导机制的研究人员和教育工作者。信号转导是细胞对内外刺激做出反应的手段。这些控制调节细胞的生理、新陈代谢和基因控制。因此，信号转导是所有细胞的基础，对理解许多病理状态至关重要。在这个项目中，申请者专注于与癌症相关的培训；癌症被称为一种信号机制异常的疾病。然而，该计划并不局限于癌症问题，涉及许多临床问题和部门。申请者建议，来自医学系、生物化学系、生理学/药理学系和微生物学/免疫学系的培训计划教员将负责七名研究员的教学和研究培训。这些研究员中有四人将是博士后，三人将是博士后。博士后可以拥有医学博士学位，也可以拥有博士学位。博士后计划为4-5年，博士后研究员为2-3年。相关部门的设施以及维克森林大学综合癌症中心的设施将向学员开放。

DESCRIPTION (Applicant's Description): The purpose of this program is to train a new generation of researchers and educators in signal transduction mechanisms. Signal transduction is the means by which cells respond to internal and external stimuli. These controls regulate the physiology, metabolism and gene control of the cell. As such, the signal transduction is fundamental to all cells and is critical to the understanding of many pathologic states. In this program the applicants focus on training related to cancer; cancer has been termed a disease of aberrant signaling mechanisms. The program, however, is not limited to problems in cancer and involves many clinical problems and departments. Here the applicants propose that the training program faculty from the Departments of Medicine, Biochemistry, Physiology/Pharmacology and Microbiology/Immunology will be responsible for the didactic and research training of seven fellows. Four of these fellows will be predoctoral and three will be postdoctoral. The postdoctorals can have either the M.D. or Ph.D. degree. The program will be 4-5 years for predoctoral and 2-3 years for postdoctoral fellows. The facilities of the Departments involved plus those of the Comprehensive Cancer Center of Wake Forest University will be available to the trainees.