Field Emission Gun Scanning Electron Microscope

克里克是医学研究理事会、英国癌症研究中心、威康信托基金会和三所顶尖大学的合作伙伴：伦敦大学学院、伦敦帝国理工学院和伦敦国王学院。克里克立志成为世界领先的医学研究机构之一。克里克通过集中的设施和功能实现了运营和研究效率以及规模经济，称为科学运营，为克里克的所有研究人员提供了先进的设备，研究动物和实验室使能功能，如电子显微镜科学技术平台（EM STP）。电子显微镜是生物科学研究的基本工具。它被用于蛋白质、病原体、细胞和组织的结构成像，以帮助我们了解正常发育的生物过程、疾病状态和治疗效果。该提案是一种新的扫描电子显微镜，将用于克里克正在进行的60多个研究项目的最先进的成像实验。显微镜可以对细胞和组织的表面进行成像，以揭示例如免疫细胞如何对抗感染，神经细胞如何连接和交流，以及药物如何对抗一系列感染因子。该显微镜具有一系列额外的功能，包括自动图像拼接，使我们能够查看大样本并数字放大到感兴趣的特征（如“谷歌地图”）;使用称为阵列断层扫描的技术对样本进行更快，更自动化的三维成像;以及冷冻台，用于成像被冰包裹的样本，尽可能接近它们的生活状态。

The Crick is a partnership between the Medical Research Council, Cancer Research UK, the Wellcome Trust and three leading universities: University College London, Imperial College London and King's College London. The Crick aspires to be one of the world's leading medical research institutes. The Crick achieves operational and research efficiencies and economies-of-scale through centralised facilities and functions, known as Science Operations, that provide all researchers at the Crick, irrespective of affiliation, with access to cutting-edge equipment, animals for research and laboratory enabling functions such as the Electron Microscopy Science Technology Platform (EM STP). Electron microscopy is a fundamental tool in bioscience research. It is used to image the structure of proteins, pathogens, cells and tissues, to help us understand the biological processes of normal development, disease states, and the effect of therapies.This proposal is for a new scanning electron microscope that will be used for state-of the-art imaging experiments for more than 60 research projects ongoing at the Crick. The microscope can image the surface of cells and tissues to reveal, for example, how immune cells fight infection, how nerve cells connect and communicate, and how drugs work against a range of infectious agents. The microscope has a range of additional features, including automated image stitching to allow us to view large samples and digitally zoom into features of interest (like 'google maps'); faster, more automated, three-dimensional imaging of samples using a technique called array tomography; and a cryo-stage for imaging samples encased in ice, as close to their living state as possible.