MODIFIABLE RISK FACTORS FOR SUDDEN DEATH IN MEN/WOMEN

描述 (摘自申请者的摘要)本临床试验的目的 调查员发展奖是为候选人克里斯汀博士做准备 阿尔伯特，医学博士，心血管领域的独立研究员 流行病学，特别强调预防和治疗 心律失常。艾伯特博士对 心源性猝死(SCD)临床综合征与生命危险 室性心律失常。申请人提出了一项为期5年的 将前瞻性地检查SCD特有的风险因素的研究 男人和女人。需要检验的假设包括： 饮食因素(特别是海洋n-3脂肪酸、α-亚麻酸 酸、镁、酒精和抗氧化剂)、性激素和阿司匹林 SCD的风险。SCD的可能诱因，包括体力活动和 焦虑，也将被检验。在女性中，SCD还没有得到很好的研究， 将进行分析，以更好地定义病理生理学。性 还将在这些分析的背景下探讨差异。这个 调查将在三个队列研究中进行：护士的 对121,700名目前年龄在50-75岁的女性的健康研究；医生的健康 1982年对22,071名40-84岁男性和女性抗氧化剂的研究 对8,172名40岁及以上女性进行的心血管研究 心血管疾病或至少三个冠状动脉危险因素。最后 队列研究为研究高危女性的SCD提供了机会。 在拟议的研究计划结束时，阿尔伯特博士将达到 先进的流行病学技能，然后可以应用于独立 研究她选择的电生理学的子专业。

DESCRIPTION (Adapted from applicants' abstract) The purpose of this Clinical Investigator Development Award is to prepare the candidate, Dr. Christine Albert, M.D., for a career as an independent investigator in cardiovascular epidemiology with a special emphasis on the prevention and treatment of cardiac arrhythmias. Dr. Albert has developed a great interest in the clinical syndrome of sudden cardiac death (SCD) and life-threatening ventricular arrhythmias. The applicant proposes a 5-year program of research that will prospectively examine risk factors specific for SCD in men and women. The hypotheses to be examined include: the influence of dietary factors (in particular, marine n-3 fatty acids, alpha-linolenic acid, magnesium, alcohol, and antioxidants), sex hormones, and aspirin on the risk of SCD. Possible triggers of SCD, including physical activity and anxiety, will also be examined. In women, SCD has not been well studied and analyses will be performed to better define pathophysiology. Sex differences will also be explored in the context of these analyses. The investigations will be performed in three cohort studies: the Nurses' Health Study of 121,700 women currently aged 50-75; the Physicians' Health Study of 22,071 men aged 40-84 years in 1982; and the Women's Antioxidant Cardiovascular Study of 8,172 women aged 40 and older with known cardiovascular disease or at least three coronary risk factors. The last cohort provides an opportunity to study SCD in women who are at high risk. At the end of the proposed research program, Dr. Albert will have attained advanced epidemiologic skills which can then be applied to independent research in her chosen subspecialty of electrophysiology.