DIET ADHERENCE INTERVENTION FOR DYSLIPIDEMIA (DIETAID)

血脂异常的饮食坚持干预 (DIETAID)

• 批准号: 6183454
• 负责人: ROBERT H FRIEDMAN
• 金额: $ 56.67万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-10 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6183454
• 关键词: behavior therapy; behavioral /social science research tag; blood lipid; clinical research; clinical trials; computer assisted instruction; computer assisted patient care; computer human interaction; computer system design /evaluation; diet therapy; human subject; human therapy evaluation; hyperlipidemia; nutrient intake activity; nutrition education; nutrition related tag; therapy compliance

DESCRIPTION: (Adapted from Investigator's Abstract) Dyslipidemia is a major risk factor for coronary heart disease (CHD). In dyslipidemia patients, dietary interventions can have a positive impact on total cholesterol and LDL-cholesterol levels and thus reduce the patients' CHD risk. Although dietary counseling can be effective in changing dietary behavior, it is used variably by physicians and their patients. DietAid (Diet Adherence Intervention for Dyslipidemia) is an automated telephone-based system that functions as a physician or nutritionist-extender. Using the NCEP Step I guidelines as the basis, DietAid monitors dietary behavior of dyslipidemia patients in their homes and provides them with nutritional information and advice and behavioral feedback to affect their dietary behavior. DietAid uses computer-controlled speech to speak. The patients communicate by depressing keys on their touch-tone telephones. Conversations take place 1-2 times a week; either DietAid or the patient can initiate a call. DietAid is based on the Telephone-Linked Communication (TLC) technology previously developed by the investigators and successfully applied to improving medication adherence and physical activity levels in patients. An initial version of DietAid was developed and tested in a randomized controlled pilot study, and was shown to be effective in lowering total cholesterol and possibly LDL-cholesterol in dyslipidemia patients. DietAid users were also very satisfied with the program (mean rating of 8 on a 1 (low) to 10 (high) scale). In this proposed project, the pilot version of DietAid will be refined into a final version and then evaluated with regard to its effect on dietary behavior, nutrient intake and serum lipid levels in a randomized clinical trial of 360 general medical patients with total cholesterol 240-299 mg/dL on entry. Subjects will be randomly assigned to DietAid or a TLC control intervention that provides general health information. The minority participation rate is expected to be 19-22%, and about 60% of the subjects will be female. Each subject will be followed for a six month period with assessments at baseline, 3 months and 6 months. The endpoints will be changes in dietary behavior (level of use of highly atherogenic foods), quantitative nutrient intake (fat and cholesterol), and serum lipid levels. The acceptability of DietAid to patient users will be measured by an attitudinal questionnaire that includes both structured and open-ended questions. DietAid's operating costs and cost effectiveness will be calculated.

描述：（改编自研究者摘要）血脂异常是一种主要的 冠心病的危险因素。 在血脂异常患者中， 饮食干预可以对总胆固醇产生积极影响， LDL-胆固醇水平，从而降低患者的CHD风险。 虽然 饮食咨询可以有效地改变饮食行为，它被用来 医生和病人都很关心。 DietAid（饮食依从性 血脂异常干预）是一个基于电话的自动系统， 作为一个医生或营养学家的扩展功能。 使用NCEP步骤I 以指南为依据，DietAid监测血脂异常的饮食行为 病人在他们的家中，并为他们提供营养信息， 建议和行为反馈来影响他们的饮食行为。 饮食援助 用电脑控制的语音说话。 患者通过以下方式进行交流 按下按键电话上的按键。 对话发生 1-2每周两次; DietAid或患者可以发起呼叫。 DietAid基于电话链接通信（TLC）技术 研究人员先前开发并成功应用于 改善患者的药物依从性和身体活动水平。 一个 DietAid的初始版本在一个随机的 对照试验研究，并被证明是有效地降低总 胆固醇和可能的LDL-胆固醇。 饮食援助 用户对该计划也非常满意（平均评分为8分， (low)10（高）等级）。 在这个拟议的项目中，DietAid的试点版本将被细化为 最终版本，然后评估其对饮食的影响， 行为、营养摄入和血脂水平的随机临床研究 360例总胆固醇240-299 mg/dL的普通内科患者试验 在入口处。 受试者将被随机分配至DietAid或TLC对照组 提供一般健康信息的干预措施。 少数 参与率预计为19- 22%，约60%的受试者 将是女性。 将对每例受试者进行为期6个月的随访， 在基线、3个月和6个月时进行评估。 终点将是 饮食行为的改变（高致动脉粥样硬化食物的使用水平）， 定量营养摄入（脂肪和胆固醇）和血脂水平。 DietAid对患者用户的可接受性将通过 包括结构化和开放式的态度问卷 问题. DietAid的运营成本和成本效益将 计算了