Optimized dosing regimens for the combinations of sulfonamides and trimethoprim in veterinary medicine

兽药中磺胺类药物与甲氧苄啶联合用药的优化给药方案

• 批准号: MR/X03173X/1
• 负责人: Ludovic Pelligand
• 金额: $ 33.72万
• 依托单位: Royal Veterinary College
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX03173X%2F1
• 关键词: Optimized; dosing; regimens; combinations; sulfonamides

Antibiotics are routinely used in both human and animal medicine to treat many serious bacterial diseases. Their use in animals is highly regulated, and ensures better health and welfare of animals. Unfortunately, use of antibiotics over many decades has led to bacteria becoming resistant to these treatments, with antimicrobial resistance being one of the biggest future health risks for humanity. The European Medicines Agency advocates the use of specific antibiotics for veterinary medicine. These are drugs which are classed as not critically important for human health. Unfortunately, since these drugs were often registered decades ago, with less requirements in terms of dose selection, it is highly probable that the dosage regimens fail to achieve optimal efficacy. Our team are cross-European specialists in veterinary clinical microbiology and pharmacology and our project is focused on optimizing dosing levels; i.e. using the correct dose at the correct time, for the correct duration, of two drugs in combination: trimethoprim and sulfonamides in seven different animal species. The use of these drugs in an optimal way will both increase the likelihood of successful treatment in animals and reduce the risk of developing further antimicrobial resistance. This project will lead to better future usage of these drugs in veterinary medicine. The use of accurate treatments will also result in lower reliance on other antibiotics which may be vital for use in human medicine.

抗生素通常用于人类和动物医学，以治疗许多严重的细菌性疾病。它们在动物中的使用受到高度管制，并确保动物更好的健康和福利。不幸的是，几十年来抗生素的使用导致细菌对这些治疗产生耐药性，抗菌素耐药性是人类未来最大的健康风险之一。欧洲药品管理局提倡在兽药中使用特定的抗生素。这些药物被归类为对人类健康不重要的药物。不幸的是，由于这些药物通常在几十年前注册，在剂量选择方面的要求较少，因此剂量方案很可能无法达到最佳疗效。我们的团队是兽医临床微生物学和药理学的跨欧洲专家，我们的项目专注于优化剂量水平;即在正确的时间使用正确的剂量，正确的持续时间，两种药物的组合：甲氧苄啶和磺胺类药物在七种不同的动物物种中。以最佳方式使用这些药物将增加在动物中成功治疗的可能性，并降低进一步产生抗生素耐药性的风险。该项目将导致这些药物在兽医学中更好的未来使用。使用准确的治疗方法也将降低对其他抗生素的依赖，这些抗生素对人类医学的使用至关重要。