Optimized dosing regimens for the combinations of sulfonamides and trimethoprim in veterinary medicine

抗生素是人类和动物药物中的常规用药，用于治疗许多严重的细菌性疾病。它们在动物中的使用受到严格监管，并确保动物更好的健康和福利。不幸的是，几十年来抗生素的使用已经导致细菌对这些治疗产生抗药性，抗菌素耐药性是人类未来最大的健康风险之一。欧洲药品管理局提倡在兽医中使用特定的抗生素。这些药物被归类为对人类健康不是至关重要的药物。不幸的是，由于这些药物往往是几十年前注册的，在剂量选择方面要求较低，因此剂量方案很可能无法达到最佳疗效。我们的团队是跨欧洲的兽医临床微生物学和药理学专家，我们的项目专注于优化剂量水平；即在正确的时间、正确的持续时间使用正确的剂量，在七种不同的动物物种中联合使用两种药物：甲氧苄啶和磺胺类药物。以最佳方式使用这些药物将增加在动物身上成功治疗的可能性，并降低进一步产生抗菌素耐药性的风险。该项目将使这些药物在兽医中得到更好的未来使用。使用准确的治疗方法还将减少对其他抗生素的依赖，这些抗生素可能对人类医学的使用至关重要。

Antibiotics are routinely used in both human and animal medicine to treat many serious bacterial diseases. Their use in animals is highly regulated, and ensures better health and welfare of animals. Unfortunately, use of antibiotics over many decades has led to bacteria becoming resistant to these treatments, with antimicrobial resistance being one of the biggest future health risks for humanity. The European Medicines Agency advocates the use of specific antibiotics for veterinary medicine. These are drugs which are classed as not critically important for human health. Unfortunately, since these drugs were often registered decades ago, with less requirements in terms of dose selection, it is highly probable that the dosage regimens fail to achieve optimal efficacy. Our team are cross-European specialists in veterinary clinical microbiology and pharmacology and our project is focused on optimizing dosing levels; i.e. using the correct dose at the correct time, for the correct duration, of two drugs in combination: trimethoprim and sulfonamides in seven different animal species. The use of these drugs in an optimal way will both increase the likelihood of successful treatment in animals and reduce the risk of developing further antimicrobial resistance. This project will lead to better future usage of these drugs in veterinary medicine. The use of accurate treatments will also result in lower reliance on other antibiotics which may be vital for use in human medicine.