STRESS AND AGING; MECHANISMS, MODELS AND INTERVENTIONS

该提案要求为2000年6月2日至5日在波士顿特雷蒙特酒店和马萨诸塞州波士顿塔夫茨大学美国农业部(USDA)人类营养老龄化研究中心举行的第29届美国老龄协会(AGE)年会的演讲者提供一年的旅费和住宿费支持。本次会议的重点是“老龄化压力：机制、模式和干预”。应激在衰老和与年龄相关的疾病中的作用的重点将包括氧化应激和环境应激的各个方面，研讨会针对潜在的机制、动物和体外模型，以及旨在改善与年龄有关的应激的负面影响的干预措施，例如限制热量和营养方案。这些主题包含了生物老年学的不同领域，这些领域在研究和公共领域受到越来越多的关注，因此将吸引具有不同背景和对老龄化有共同兴趣的科学家。会议由六个专题组成：I线粒体参与氧化应激和衰老的机制；II氧化应激的细胞影响；III氧化应激与神经变性；IV抗氧化剂和干预；V生理应激的综合反应；VI应激反应的分子特征。除了六个研讨会外，6月2日还将举行一个会议前研讨会，题为“DNA微阵列在衰老研究中的应用”。研讨会将为知名研究人员和学生提供一个机会，让他们了解这一令人兴奋的方法、重要的技术考虑以及将其应用于生物老年学许多领域的可能性。最后，塔夫茨大学人类老龄化营养研究中心将于6月5日主办题为“饮食干预老龄化与年龄相关疾病”的研讨会。

The proposal requests the single-year support of travel and lodging expenses for speakers at the 29th annual American Aging Association (AGE) meeting being held June 2 - 5, 2000, at the Tremont Boston hotel and the Jean Mayer United States Department of Agriculture (USDA) Human Nutrition Research Center on Aging at Tufts University in Boston, Massachusetts. The emphasis of this meeting is "Stress in Aging: Mechanisms, Models and Interventions." The focus on the involvement of stress in aging and age-related diseases will include aspects of both oxidative and environmental stresses with symposia directed at potential mechanisms, animal and in vitro models, and interventions aimed at ameliorating the negative impact of age-related stresses, e.g., caloric restriction and nutritional regimens. These topics incorporate diverse areas of biogerontology which are receiving increasing attention in the research and public communities and will, therefore, attract scientists with divergent backgrounds and a common interest in aging. The meeting consists of six symposia: I Mechanisms of Mitochondrial Involvement in Oxidative Stress and Aging; II Cellular Impact of Oxidative Stress; III Oxidative Stress and Neurodegeneration; IV Antioxidants and Interventions; V Integrated Responses to Physiological Stress; VI Molecular Characterization of the Stress Response. In addition to the six symposia, there will be a preconference workshop on June 2nd entitled, "DNA Microarrays in the Study of Aging." The workshop will provide an opportunity for both established researchers and students to learn about this exciting methodology, important technical considerations and the possibilities for its application to many areas of biogerontology. Lastly, a symposium entitled, "Dietary Interventions in Aging and Age-Associated Disease" will be sponsored by the Human Nutrition Research Center on Aging at Tufts University on June 5th.