Development of specific modulators of voltage-gated sodium channels

电压门控钠通道特异性调节剂的开发

• 批准号: nhmrc : 1035102
• 负责人: Dr Linlin Ma
• 金额: $ 25.64万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-specific-modulators-sodium-channels/110948
• 关键词: Development; specific; modulators; voltage; gated

This project will identify novel modulators of voltage-gated sodium (NaV) channels, a type of sodium-conducting integral membrane proteins, which play a central role in neuronal, muscular, and cardiac function. These modulators will be characterized in order to understand how they modify channel function and to aid their development as analgesics for the treatment of chronic pain.

该项目将识别电压门控钠（NaV）通道的新型调节剂，电压门控钠（NaV）通道是一种钠传导膜整合蛋白，在神经元、肌肉和心脏功能中发挥核心作用。这些调节剂将被表征，以了解它们如何改变通道功能，并帮助它们开发为用于治疗慢性疼痛的镇痛剂。