HUMAN AMYGDALA-LIMBIC LESIONS AND EMOTIONAL BEHAVIOR

人类杏仁核边缘系统损伤和情绪行为

• 批准号: 6208237
• 负责人: TRICIA Z KING
• 金额: $ 3.09万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6208237
• 关键词: Alphaherpesvirinae; behavioral /social science research tag; brain injury; clinical research; emotions; human subject; infectious encephalitis; limbic system; memory; neurosurgery

Disorders of emotion are a leading cause of human suffering and disability, yet emotion is one of the least studied biological phenomena. Decades of animal studies have demonstrated that damage to amygdala systems is responsible for changes in emotional behavior, but these studies have not fully accounted for the complexity and richness of human emotional experience. This study will examine how acquired lesions of the amygdala and associated limbic areas caused by either herpes simplex encephalitis (HSE) or temporal lobectomy (TLE) affect emotional behavior. The specific aims of this project are to determine the impact of amygdala lesions on: 1) emotional response systems (i.e., self-report, behavior, and psychophysiology), 2) appetitive and aversive motivational systems (i.e., emotional valence) and 3) memory for standard emotionally evocative photographs. This project will be among the first to examine these areas in amygdala lesioned patients using a standard paradigm and normative emotionally-laden stimuli. My vision is to utilize an NRSA Fellowship to collect data that will provide information relevant to better understanding the underlying mechanisms of emotion and memory. I plan to use the data collected from this study to submit a future NIH R01 grant that will focus on further delineation of the neural systems involved in emotional processing and memory. Identification of the crucial, interacting neural systems in emotional behavior will lead to better interventions for debilitating psychological conditions.

情感疾病是人类苦难和残疾的主要原因，但情感是研究最少的生物学现象之一。数十年的动物研究表明，对杏仁核系统的损害是导致情感行为变化的原因，但是这些研究并未充分说明人类情感体验的复杂性和丰富性。这项研究将研究由疱疹单纯脑炎（HSE）或颞叶切除术（TLE）引起的杏仁核和相关边缘区域的损伤如何影响情绪行为。该项目的具体目的是确定杏仁核病变对：1）情绪反应系统（即自我报告，行为和心理生理学），2）2）），2）对标准的情感情感摄影照片的食用和厌恶动机系统（即情感价值）和3）记忆。该项目将是最早使用标准范式和规范性情感刺激的杏仁核病变患者中这些区域的项目之一。我的愿景是利用NRSA奖学金来收集数据，这些数据将提供有关更好地理解情感和记忆的潜在机制的信息。 我计划使用这项研究收集的数据提交未来的NIH R01赠款，该赠款将重点介绍进一步描述情感处理和记忆中涉及的神经系统。 在情感行为中识别至关重要的，相互作用的神经系统将导致更好的干预心理状况。