Development of therapeutic strategies based on mechanisms of receptors and ion channels in neural circuits mediating chronic pain and opioid dependence

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Chronic pain is a growing and poorly treated global health burden. There is a great need for novel pain therapeutics. We are discovering novel drug targets in pain pathways in the nervous system and new therapeutic molecules that selectively block information flow in pain nerves. Strong pain relieving drugs like morphine also lose their effectiveness after long periods of use. We are finding mechanisms responsible for this thereby providing a rational basis for development of better opioids and pain treatments.