Development of therapeutic strategies based on mechanisms of receptors and ion channels in neural circuits mediating chronic pain and opioid dependence

基于介导慢性疼痛和阿片类药物依赖的神经回路中的受体和离子通道机制开发治疗策略

• 批准号: nhmrc : 1045964
• 负责人: Prof Macdonald Christie
• 金额: $ 68.55万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-therapeutic-strategies-opioid-dependence/111802
• 关键词: Development; therapeutic; strategies; based; mechanisms

Chronic pain is a growing and poorly treated global health burden. There is a great need for novel pain therapeutics. We are discovering novel drug targets in pain pathways in the nervous system and new therapeutic molecules that selectively block information flow in pain nerves. Strong pain relieving drugs like morphine also lose their effectiveness after long periods of use. We are finding mechanisms responsible for this thereby providing a rational basis for development of better opioids and pain treatments.

慢性疼痛是一个日益严重且治疗不善的全球健康负担。对新型疼痛疗法的需求很大。我们正在发现神经系统疼痛通路中的新药物靶点和选择性阻断疼痛神经信息流的新治疗分子。吗啡等强效止痛药在长期使用后也会失去效力。我们正在寻找对此负责的机制，从而为开发更好的阿片类药物和疼痛治疗提供合理的基础。