PRECISE 3-D QCT TO MONITOR OSTEOPOROSIS THERAPY

描述：研究人员建议测试开发一种 用于定量X射线计算机断层摄影的三维方法 测量骨质疏松症及其在治疗下的长期进展， 进一步描述了他们的摘要： “越来越多的妇女接受骨质疏松症治疗， 强调了快速确定治疗功效的益处。解决 这一需要，我们将开发一种精确的三维定量计算机断层扫描（QCT） 技术来量化高反应性骨小梁的密度， 脊椎和臀部我们将通过以下方式实现这一目标：（i）开发自动化 技术来描绘感兴趣的小梁和皮质区域， 3D图像中的解剖标志，以及（ii）通过解决 与校准参考之间的耦合变化相关的误差 体模和患者。在第一阶段，我们将执行两项任务。一是 三种分析算法实现及商业可行性评估 体积QCT图像，将它们相互比较并与标准2D图像进行比较 法其次，我们将在体外测量精度的大小 与临床观察到的患者体模变化相关的误差 偶合器.我们将确定改进耦合是否会降低精度 错误.在第二阶段，我们将在商业上开发算法， 最佳表现。如果耦合测量的结果显示可测量的 对精度误差的影响，我们将构建并评估一个体模， 改进患者体模耦合。" 拟定商业应用：不可用

DESCRIPTION: The investigators propose to test the feasibility of developing a three-dimensional method for quantitative X-ray computed tomographic measurement of osteoporosis and its long term progression under treatment, as further described by their abstract: "The large and increasing number of women being treated for osteoporosis underscores the benefit of rapid determination of therapy efficacy. To address this need, we will develop a precise 3D quantitative computed tomography (QCT) technique to quantify the density of the highly-responsive trabecular bone in the spine and hip. We will accomplish this by (i) by developing automated techniques to delineate trabecular and cortical regions of interest based on anatomic landmarks in the 3D images and (ii) by addressing a key source of error associated with variations in coupling between the calibration reference phantom and patient. In Phase I, we will perform two tasks. First, we will implement and evaluate for commercial feasibility three algorithms for analysis of volumetric QCT images, comparing them to each other and to the standard 2D technique. Second, we will measure in vitro the magnitude of the precision error associated with clinically-observed variations in phantom-patient coupling. We will determine whether improving the coupling reduces precision errors. In Phase II, we will commercially develop the algorithm shown to have best performance. If the results of the coupling measurements show a measurable effect on precision error, we will build and evaluate a phantom designed to improve patient phantom coupling." PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE