ADAPTIVE SUPPORT ENVIRONMENT FOR ALCOHOL DEPENDENCE

针对酒精依赖的适应性支持环境

• 批准号: 6074629
• 负责人: CORINNE M MAR
• 金额: $ 10万
• 依托单位: TALARIA, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6074629
• 关键词: alcoholism /alcohol abuse; alcoholism /alcohol abuse chemotherapy; clinical research; computer program /software; computer system design /evaluation; coping; human subject; human therapy evaluation; interactive multimedia; psychosocial rehabilitation; social support network; therapy compliance

The societal costs of alcoholism are substantial; estimated at almost $100 billion each year. An effective approach to alcoholism combines psychosocial therapy with medications. Unfortunately there remains a high drop-out rate from therapy and limited compliance with medication regiments. This project, Adaptive Support Environment for Alcohol Dependence (ASEAD), aims to reduce relapse in the early stages of alcohol treatment by providing patients with support during the high risk periods between therapy sessions. ASEAD does not replace standard therapy but is a tool to enhance therapy by providing patients assistance in real-time, 24 hours a day. Support is directed at two important components of successful treatment, better medication adherence and enhanced psychosocial support. Patients, between clinic visits, carry telecommunications devices that provide an interactive platform for therapeutic interventions. The interventions adapt to the changing needs of the patient. The system consists of data entry templates, databases of algorithms and messages, and analysis and communication software. Improvements in adherence or treatment retention rates will have a significant impact on the success of both clinical trials and therapeutic care. Phase 1 creates a working prototype and tests the system with a sample of subjects. Phase 2 will enhance the system and evaluate it through a randomized controlled trial. PROPOSED COMMERCIAL APPLICATION: Over 500,000 people/year seek alcohol treatment. The NIAAA currently funds 20 pharmacotherapy trails. The price of noncompliance and relapse is very expensive and provides and attractive target for innovations that reduce costs. Talaria, Inc. anticipates licensing this system for clinical trials and clinical care. Other markets include asthma and weight reduction.

酗酒的社会成本是巨大的;估计 每年近1000亿美元。一个有效的方法来酗酒结合 用药物进行心理社会治疗不幸的是， 治疗的脱落率和对药物治疗方案的依从性有限。 这个项目，酒精依赖的适应性支持环境（ASEAD），目的是 在酒精治疗的早期阶段， 在治疗疗程之间的高风险期给予支持的患者。 ASEAD不能取代标准治疗，但它是一种通过以下方式增强治疗的工具： 每天24小时为患者提供实时帮助。支持是针对 成功治疗的两个重要组成部分，更好的药物治疗 坚持和加强心理支持。患者在门诊访视之间， 携带提供交互平台的电信设备， 治疗干预。干预措施适应了不断变化的需求， 病人该系统由数据录入模板、算法数据库组成 和信息，以及分析和通信软件。改善 依从性或治疗保留率将对 临床试验和治疗护理的成功。第一阶段创建一个工作 原型和测试系统与一个样本的主题。第二阶段将加强 系统，并通过随机对照试验进行评价。 拟定商业应用： 每年有超过50万人寻求酒精治疗。目前，该基金会资助20 药物治疗试验不依从和复发的代价是非常昂贵的， 为降低成本的创新提供了有吸引力的目标。Talaria公司预计 为临床试验和临床护理颁发许可证。其他市场包括哮喘和 减轻体重。