COMPUTER-ASSISTED STEREOLOGY FOR MOUSE BRAIN DATABASE

小鼠大脑数据库的计算机辅助立体学

• 批准号: 6016661
• 负责人: Floyd Elliott Bloom
• 金额: $ 27.38万
• 依托单位: YBM SOFTWARE ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6016661
• 关键词: Internet; animal data; bioimaging /biomedical imaging; brain mapping; computational neuroscience; computer program /software; computer system design /evaluation; disease /disorder model; genetically modified animals; image processing; information systems; laboratory mouse; structural biology; superoxide dismutase

DESCRIPTION: (Verbatim from the Applicant's Abstract) The need to extract quantitative brain structural data has increased substantially with the proliferation of genetically manipulated mice as models of CNS disorders. Software developed under their Human Brain Project consortium define the structural bases for normal and pathologic brain function in animal models. Under the Phase I grant, they have established the need for a commercial version of NeuroZoom with networking and integrated atlases. They have developed and validated new stereology probes by performing stereological analyses of transgenic mice with a point mutation in the mouse superoxide dismutase (SOD-1) gene. In this Phase 2 application, they will: 1) develop NeuroZoom into a commercially-supported, cross-platform application and extend it to the Web, 2) develop software to integrate an electronic mouse atlas on C57BU6 and SV1 29, and 3) map out a related set of proteins in transgenic and normative mouse models. They believe that the potential customers for these products are: 1) laboratories possessing sufficient expertise to carry out the analyses in-house with their software; 2) biotechnology firms developing lines of transgenic mice and outsourcing for their comprehensive structural characterization; and 3) pharmaceutical companies that need assistance in developing an on-site program for their analyses. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：(逐字摘自申请人的摘要)需要摘录 定量的大脑结构数据随着 作为中枢神经系统疾病模型的基因操作小鼠的增殖。 在他们的人脑项目联盟下开发的软件定义了 动物模型中正常和病理脑功能的结构基础。 根据第一阶段拨款，他们已经确定了商业广告的必要性 具有联网和集成地图集的NeuroZoom版本。他们有 通过进行体视学检查，开发并验证了新的体视学探针 小鼠超氧化物歧化点突变转基因小鼠的分析 歧化酶(SOD-1)基因。 在这个第二阶段的应用中，他们将：1)将NeuroZoom开发为 商业支持的跨平台应用程序，并将其扩展到网络，2) 开发软件在C57BU6和SV1 29上集成电子鼠标图谱， 3)在转基因小鼠和正常小鼠中绘制一组相关的蛋白质 模特们。 他们认为这些产品的潜在客户是：1) 拥有足够专业知识在内部进行分析的实验室 和他们的软件；2)生物技术公司开发转基因小鼠品系 以及外包其全面的结构特征；以及3) 在制定现场计划方面需要帮助的制药公司 用于他们的分析。 建议的商业应用：不可用