PRECLINICAL TOXICOLOGY & PHARMACOLOGY OF DRUGS DEVELOPED

临床前毒理学

• 批准号: 6324185
• 负责人: CHARLES A TYSON
• 金额: --
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6324185
• 关键词: AIDS therapy; Primates; Rodentias; antiAIDS agent; antineoplastics; dogs; dosage; drug administration routes; drug screening /evaluation; mass spectrometry; neoplasm /cancer chemotherapy; neoplasm /cancer pharmacology; nonhuman therapy evaluation; nuclear magnetic resonance spectroscopy; pharmacokinetics; pharmacology; toxicology

The objective of this contract is to acquire pharmacologic and toxicologic data on new drugs for the treatment of Cancer and the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-related illnesses. The data will be included in an Investigational New Drug (IND) application to the FDA which is required prior to the initiation of human clinical trials. Level A contract is 46,875 hours over 5 years. Level B contract is 93,750 hours over 5 years. This contract will be awarded at Level A because the laboratory has the capability, expertise and experience to do the amount of work required.

本合同的目的是获得药理学和 治疗癌症新药的毒理学数据 获得性免疫缺陷综合症（艾滋病）和艾滋病相关疾病。 该数据将包含在研究性新药 (IND) 中 在启动之前需要向 FDA 提出申请 人体临床试验。 A 级合同为 5 年 46,875 小时。 B级合同是 5 年 93,750 小时。 本合同将授予 A 级合同 因为实验室有能力、专业知识和经验 完成所需的工作量。