COMBINING EEG, MEG, FMRI

该项目的目的是提供一种新的方法来结合不同的非侵入性脑成像技术，即脑电图（EEG）、脑磁图（MEG）、磁共振成像（MRI）和功能磁共振成像（fMRI），以克服电生理技术的空间分辨率差和功能磁共振成像的时间分辨率低，从而提供一个更完整的大脑时空动态视图。该方法利用核磁共振成像的能力来定位大脑中在任务中被激活的三维区域。关键功能包括关注从fMRI扫描中识别的感兴趣区域，计算正解而不是解决逆问题。了解这些激活部位皮层表面的折叠或局部形状，可以找到一组传感器的权重系数，以提高磁力计或电极组对这些特定区域的灵敏度，即专注于活动区域。结果将使我们能够以脑电或脑磁图的时间分辨率（毫秒）观察局部活动的时间过程。本项目使用的数据集将包括143通道脑磁图、120电极脑电图、高分辨率MRI和功能磁共振成像，这些数据将于1999年在同一受试者的听觉-运动协调和听觉感知任务中使用所有技术进行记录。这个数据库将在我们的网站上提供，其他研究人员可以使用它来测试和改进分析和可视化算法。

The aim of this project is to provide a new approach to combining the different non-invasive brain imaging technologies, i.e. electroencephalography (EEG), magnetoencephalography (MEG), magnetic resonance imaging (MRI) and functional MRI (fMRI) in order to overcome the poor spatial resolution of the electrophysiological techniques and the low temporal resolution of fMRI thus providing a more complete view of spatiotemporal brain dynamics. The approach takes advantage of the capabilities of MRI to locate the 3-d regions inside the brain that are activated during a task. Key features include focusing on regions of interest identified from fMRI scans and calculating forward solutions instead of solving an inverse problem. Knowledge of the folding or local shape of the cortex surface at these activation sites allows for a set of weight coefficients for sensors to be found to increase the sensitivity of the magnetometer or set of electrodes for these particular regions, i.e. to focus on the activity regions. The outcome will enable us to observe the time course of local activities with the temporal resolution of EEG or MEG (milliseconds). The dataset to be used in this project will consist of 143- channel MEG, 120-electrode EEG, high-resolution MRI and fMRI to be recorded in 1999 with all technologies from the same subjects during auditory-motor coordination and auditory perception tasks. This database will be made available on our web site and can be used by other researchers to test and improve analysis and visualization algorithms.